MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS
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MicroRNAs (miRNAs) play several important roles in carcinogenesis, and the dysregulation of miRNAs is associated with cancer progression. Little is known about the role of miR-613 in ovarian cancer. In the present study, we demonstrate that miR-613 expression is downregulated in human ovarian cancer cell lines and tissues. Additionally, miR-613 overexpression suppressed ovarian cancer cell proliferation, colony formation, and invasion. Furthermore, KRAS was identified as a target of miR-613. Reintroducing KRAS rescued the inhibitory effects exerted by miR-613 on ovarian cancer cell proliferation and invasion. Taken together, our findings suggest that miR-613 functions as a candidate tumor suppressor miRNA in ovarian cancer by directly targeting KRAS. To the best of our knowledge, this is the first study to show that miR-613 affects the proliferation and invasion of ovarian cancer.
KeywordsOvarian cancer MicroRNAs miR-613 KRAS
This work was supported by the National Natural Science Foundation of China (Grant NO. 81301895) and Shandong Province Natural Science Foundation, China (Grant NO. ZR2012HQ009, NO. ZR2013HQ042)
Compliance with ethical standards
All of the patients provided written informed consent. This study was approved by the Ethics Committee of Tianjin Medical University Cancer Institute and Hospital and complied with the Declaration of Helsinki.
Conflicts of interest
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