Tumor Biology

, Volume 37, Issue 5, pp 6477–6483 | Cite as

MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS

Original Article

Abstract

MicroRNAs (miRNAs) play several important roles in carcinogenesis, and the dysregulation of miRNAs is associated with cancer progression. Little is known about the role of miR-613 in ovarian cancer. In the present study, we demonstrate that miR-613 expression is downregulated in human ovarian cancer cell lines and tissues. Additionally, miR-613 overexpression suppressed ovarian cancer cell proliferation, colony formation, and invasion. Furthermore, KRAS was identified as a target of miR-613. Reintroducing KRAS rescued the inhibitory effects exerted by miR-613 on ovarian cancer cell proliferation and invasion. Taken together, our findings suggest that miR-613 functions as a candidate tumor suppressor miRNA in ovarian cancer by directly targeting KRAS. To the best of our knowledge, this is the first study to show that miR-613 affects the proliferation and invasion of ovarian cancer.

Keywords

Ovarian cancer MicroRNAs miR-613 KRAS 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant NO. 81301895) and Shandong Province Natural Science Foundation, China (Grant NO. ZR2012HQ009, NO. ZR2013HQ042)

Compliance with ethical standards

Ethics statement

All of the patients provided written informed consent. This study was approved by the Ethics Committee of Tianjin Medical University Cancer Institute and Hospital and complied with the Declaration of Helsinki.

Conflicts of interest

None

Supplementary material

13277_2015_4507_MOESM1_ESM.docx (13 kb)
Table S1 (DOCX 12 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Gynecology Cancer, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Prevention and TherapyTianjin Medical University Cancer Institute and HospitalTianjinChina
  2. 2.Department of Radiation OncologyShandong Cancer Hospital and InstituteJinanChina

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