Tumor Biology

, Volume 37, Issue 5, pp 6337–6342 | Cite as

Inflammation and chemerin in colorectal cancer

  • Serpil Erdogan
  • Fatma Meric Yilmaz
  • Ozan Yazici
  • Ahmet Yozgat
  • Sevilay Sezer
  • Nuriye Ozdemir
  • Sema Uysal
  • Tugrul Purnak
  • Mehmet Ali Sendur
  • Ersan Ozaslan
Original Article


Chemerin is expressed mainly in the adipose tissue. It is an agonist of chemokine-like receptor-1, which is expressed by the immune system cells. Chemerin stimulates the chemotaxis of the immune system cells, and this indicates the function of chemerin and chemokine-like receptor-1 in the immune response. The tumor microenvironment is very important for determining cancer cell growth and spreading. Therefore, we aimed to investigate the association between colorectal cancer, inflammation, and adipokines including chemerin, adiponectin, and vaspin. The study group consisted of patients with colon cancer, whereas the control subjects consisted of patients with benign conditions, diagnosed with colonoscopy. The two groups were compared in terms of the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, adiponectin, chemerin, and vaspin. A total of 41 (28 men, 13 women) patients with confirmed colon cancer, and 27 (15 men, 12 women) controls without, confirmed by colonoscopy, were enrolled. The median chemerin levels were found significantly higher in the study group than the controls (390 vs. 340 ng/mL, p = 0.032), whereas the mean vaspin and adiponectin levels were not significantly different. The median values for the CRP, fibrinogen, and ESR were significantly higher in the patients with colon cancer, when compared to the control group (6.08 vs. 1.4 mg/L, p < 0.0001; 408 vs. 359 mg/dL, p = 0.002; and 30 vs. 8 mm/h, p < 0.0001, respectively). Our results show that higher levels of circulating chemerin, CRP, fibrinogen, and ESR are associated with an increased risk of developing colorectal cancer.


Colorectal cancer C-reactive protein Inflammation Fibrinogen Erythrocyte sedimentation rate Chemerin 



This study is supported by the Ankara Numune Training and Research Hospital (grant number 492/2012).

Compliance with ethical standards

This study was conducted in the Department of Medical Oncology and Gastroenterology at Numune Training and Research Hospital in Ankara, Turkey, with the approval of the local ethics committee. Informed consent was obtained from all individual participants included in the study.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Serpil Erdogan
    • 1
  • Fatma Meric Yilmaz
    • 2
  • Ozan Yazici
    • 3
  • Ahmet Yozgat
    • 4
  • Sevilay Sezer
    • 5
  • Nuriye Ozdemir
    • 3
  • Sema Uysal
    • 6
  • Tugrul Purnak
    • 7
  • Mehmet Ali Sendur
    • 8
  • Ersan Ozaslan
    • 4
  1. 1.Department of Clinical BiochemistryAtaturk Training and Research HospitalAnkaraTurkey
  2. 2.Faculty of Medicine, Department of Clinical BiochemistryYildirim Beyazit UniversityAnkaraTurkey
  3. 3.Department of Medical OncologyNumune Training and Research HospitalAnkaraTurkey
  4. 4.Department of GastroenterologyNumune Training and Research HospitalAnkaraTurkey
  5. 5.Department of Clinical BiochemistryNumune Training and Research HospitalAnkaraTurkey
  6. 6.Department of Clinical Biochemistry, Faculty of MedicineOnsekiz Mart UniversityCanakkaleTurkey
  7. 7.Department of Gastroenterology, Faculty of MedicineHacettepe UniversityAnkaraTurkey
  8. 8.Department of Medical OncologyAtaturk Training and Research HospitalAnkaraTurkey

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