Tumor Biology

, Volume 37, Issue 1, pp 105–114 | Cite as

IL-22: a promising candidate to inhibit viral-induced liver disease progression and hepatocellular carcinoma

  • Muhammad Saalim
  • Saleha Resham
  • Sobia Manzoor
  • Hassam Ahmad
  • Shahla Jaleel
  • Javed Ashraf
  • Muhammad Imran
  • Sidrah Naseem


Hepatocellular carcinoma (HCC) is a growing concern all over the world. With the number of patients rising exponentially with each passing day, HCC is a problem that needs immediate attention. Currently, available treatment strategies focus on controlling the damage after the development of HCC. The options available from chemo- and radio-embolization to surgical resection and transplantation are not efficacious as required due to the complex nature of the disease. Liver regeneration and tissue healing are the subject of great interest today. Interleukin-22 (IL-22) is a cytokine with the ability to regenerate and therefore reverse the injuries caused by a wide range of agents. IL-22 acts via STAT molecule and controls the activity of a wide variety of cell survival and proliferation genes. Experimental data has given a positive insight into the role of IL-22 in inhibition of viral and alcohol-induced hepatocellular carcinoma. A further insight into the nature of IL-22 and the factors that can be manipulated in controlling the activity of IL-22 can help to counter the menace caused by the devastating effects of HCC.


Hepatocellular carcinoma IL-22 Liver regeneration 


Authors’ contributions

Muhammad Saalim and Saleha Resham performed the conception and design, acquisition of data, analysis and interpretation of data, and drafting of the article. Sobia Manzoor is the principal investigator and did the conception and design, analysis and interpretation of data, critical revision of the article, and final approval of the version to be published. Shahla Jaleel, Hassam Ahmad and Javed Ashraf participated in the critical revision of the article. Javed Ashraf, Muhammad Imran and Sidrah Naseem contributed in drafting the article.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Muhammad Saalim
    • 1
  • Saleha Resham
    • 1
  • Sobia Manzoor
    • 1
  • Hassam Ahmad
    • 2
  • Shahla Jaleel
    • 3
  • Javed Ashraf
    • 4
  • Muhammad Imran
    • 1
  • Sidrah Naseem
    • 1
  1. 1.Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare BiotechnologyNational University of Sciences and TechnologyIslamabadPakistan
  2. 2.Hepatopancreatobiliary Liver Transplant UnitShaikh Zayd HospitalLahorePakistan
  3. 3.Department of HistopathologyShaikh Zayd HospitalLahorePakistan
  4. 4.Islam Dental CollegeSialkotPakistan

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