Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer
MiR-92a was identified as an essential oncogene by promoting the cell proliferation through FBXW7 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-92a (rs9589207) has not been investigated. We found that rs9589207 in miR-92a was involved in the occurrence of GC by acting as a tumor protective factor and was highly associated with tumor size in GC patients instead of tumor number or metastasis in 554 GC patients and 531 cancer-free controls. Besides, the AA genotype in miR-92a could attenuate the promoting function of miR-92a in cell proliferation with an incapacitation in downregulating the expression of FBXW7. In conclusion, rs9589207 in miR-92a was highly associated with a decreased risk of GC in Chinese Han population and might serve as a novel biomarker for the disease.
KeywordsGenotype MiR-92a Tumor growth FBXW7 SNP
This work was supported by the Social Development Technology Projects of Kunshan City, China (KS1255 to Changming Liu), Wujin Science and Technique Development Foundation (social development) (WS201414 to Lixin Jiang), Clinical Science and Technique Development Foundation of Jiangsu University (20140039 to Lixing Jiang), and Medical science and technology innovation project of Nanjing Military Region (no. 14ZD24 to Daping Xiao).
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Conflicts of interest
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