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Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer

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Tumor Biology

Abstract

MicroRNAs encoded by the miR-15b/16-2 cluster act as tumor suppressors. Aberrant regulation of miR-15b in human malignant tumors is reportedly involved in cancer development, contributing to cell death, reduced proliferation, angiogenesis and metastasis resistance, metabolism reprogramming, genome instability, and tumor-associated inflammation. In this review, we summarize the mechanisms involved in regulating miR-15b expression in mammalian tumors and discuss the effects of miR-15b dysregulation on the hallmarks of cancer and highlight its role as a potentially valuable target for future cancer therapeutic strategies.

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (No. 81172265), Supporting Certificated of Heilongjiang Postdoctoral Scientific Research Developmental Fund (No. LBH-Q14108), and Start Funding of The Affiliated Tumour Hospital of Harbin Medical University (No.YRC2014-01).

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Authors and Affiliations

  1. Department of Gastrointestinal Medical Oncology, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, Heilongjiang, China

    Ci Zhao, Guanyu Wang, Yuanyuan Zhu, Feihu Yan, Chunhui Zhang & Yanqiao Zhang

  2. Department of Pathology, Harbin Medical University, Harbin, China

    Xiaobo Li

  3. Department of Biotherapy, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, Heilongjiang, China

    Xiaoyi Huang

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  1. Ci Zhao
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  2. Guanyu Wang
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  3. Yuanyuan Zhu
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  4. Xiaobo Li
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  5. Feihu Yan
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  6. Chunhui Zhang
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  7. Xiaoyi Huang
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  8. Yanqiao Zhang
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Correspondence to Yanqiao Zhang.

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Zhao, C., Wang, G., Zhu, Y. et al. Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer. Tumor Biol. 37, 177–183 (2016). https://doi.org/10.1007/s13277-015-4269-2

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  • DOI: https://doi.org/10.1007/s13277-015-4269-2

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