Tumor Biology

, Volume 37, Issue 1, pp 177–183 | Cite as

Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer

  • Ci Zhao
  • Guanyu Wang
  • Yuanyuan Zhu
  • Xiaobo Li
  • Feihu Yan
  • Chunhui Zhang
  • Xiaoyi Huang
  • Yanqiao Zhang


MicroRNAs encoded by the miR-15b/16-2 cluster act as tumor suppressors. Aberrant regulation of miR-15b in human malignant tumors is reportedly involved in cancer development, contributing to cell death, reduced proliferation, angiogenesis and metastasis resistance, metabolism reprogramming, genome instability, and tumor-associated inflammation. In this review, we summarize the mechanisms involved in regulating miR-15b expression in mammalian tumors and discuss the effects of miR-15b dysregulation on the hallmarks of cancer and highlight its role as a potentially valuable target for future cancer therapeutic strategies.


MicroRNAs MiR-15b Angiogenesis and metastasis Metabolism 



This work is supported by the National Natural Science Foundation of China (No. 81172265), Supporting Certificated of Heilongjiang Postdoctoral Scientific Research Developmental Fund (No. LBH-Q14108), and Start Funding of The Affiliated Tumour Hospital of Harbin Medical University (No.YRC2014-01).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Ci Zhao
    • 1
  • Guanyu Wang
    • 1
  • Yuanyuan Zhu
    • 1
  • Xiaobo Li
    • 2
  • Feihu Yan
    • 1
  • Chunhui Zhang
    • 1
  • Xiaoyi Huang
    • 3
  • Yanqiao Zhang
    • 1
  1. 1.Department of Gastrointestinal Medical OncologyThe Affiliated Tumour Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of PathologyHarbin Medical UniversityHarbinChina
  3. 3.Department of BiotherapyThe Affiliated Tumour Hospital of Harbin Medical UniversityHarbinChina

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