Tumor Biology

, Volume 37, Issue 3, pp 3887–3895 | Cite as

Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer

  • Xiaosheng He
  • Xutao Lin
  • Muyan Cai
  • Xiaobin Zheng
  • Lei Lian
  • Dejun Fan
  • Xiaojian Wu
  • Ping Lan
  • Jianping Wang
Original Article


It has been suggested that hexokinase 1 (HK1) is involved in tumorigenesis. However, the expression dynamics of HK1 and its prognostic significance in human colorectal cancer (CRC) still remain unclear. The aim of the present study was to investigate the expression of HK1 and its prognostic significance in CRC. In this study, immunohistochemical analysis was used to examine the expression dynamics of HK1 in CRC tissues from two independent cohorts. Receiver operating characteristic curve analysis, Kaplan–Meier curves, and Cox regression analysis were utilized to investigate the prognostic significance. Results showed that a high expression of HK1 was observed in 106 of 393 (27.0 %) and 69 of 229 (30.1 %) of CRC in the training cohort and validation cohort, respectively. Further correlation analyses indicated that the increased HK1 expression was strongly correlated with the pN classification and TNM stage. Both cohorts showed a close association between the overexpression of HK1 and poorer overall survival. Importantly, multivariate analysis identified HK1 expression in CRC as an independent prognostic factor. Overexpression of HK1 may act as a significant biomarker of poor prognosis for patients with CRC.


Colorectal cancer Hexokinase Prognosis Biomarker 


Compliance with ethical standards

This study was approved by the IRB of the Sixth Affiliated Hospital and Cancer Center, Sun Yat-sen University.

Conflicts of interest


Declaration of funding interests

This work is supported by the National Natural Science Foundation of China (81400604).


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Xiaosheng He
    • 1
    • 2
  • Xutao Lin
    • 1
    • 2
  • Muyan Cai
    • 3
    • 4
  • Xiaobin Zheng
    • 1
    • 2
  • Lei Lian
    • 1
    • 2
  • Dejun Fan
    • 1
    • 2
  • Xiaojian Wu
    • 1
    • 2
  • Ping Lan
    • 1
    • 2
  • Jianping Wang
    • 1
    • 2
  1. 1.Department of Colorectal Surgery, the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  2. 2.Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  3. 3.State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer MedicineGuangzhouChina
  4. 4.Department of PathologySun Yat-sen University Cancer CenterGuangzhouChina

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