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Tumor Biology

, Volume 37, Issue 3, pp 3841–3850 | Cite as

Naringin suppresses the metabolism of A375 cells by inhibiting the phosphorylation of c-Src

  • Bingyu Guo
  • Yu Zhang
  • Qiang Hui
  • Hongyi Wang
  • Kai TaoEmail author
Original Article

Abstract

Elevation of glycolysis, increase in lactic acid production, and enhancement of mitochondrial biogenesis are all the changes of energy metabolism of melanoma cells. Melanoma cells’ metabolism and energy production networks play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Since the Warburg theory was put forward in the 1930s, more researchers focus on finding new ways for effectively eliminating cancer cells by targeting their energy metabolism. In this study, we found naringin has the inhibitory effects on the glucose metabolism of A375 cells, a melanoma cell line, in a concentration-dependent manner. We also found that naringin could significantly reduce the phosphorylation of c-Src. In summary, we demonstrated that naringin inhibits the malignant phenotype of A375 cells by suppressing c-Src and its downstream signaling pathway. More importantly, we provide the novel mechanism that, as a natural inhibitor of c-Src, naringin could be an effective candidate for the treatment of melanoma.

Keywords

Naringin A375 cells c-Src Signaling pathway Metabolism 

Notes

Compliance with ethical standards

Conflict of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Bingyu Guo
    • 1
  • Yu Zhang
    • 1
  • Qiang Hui
    • 1
  • Hongyi Wang
    • 1
  • Kai Tao
    • 1
    Email author
  1. 1.Reconstructive and Plastic SurgeryThe General Hospital of Shenyang Military RegionShenyangChina

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