Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy
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The αvβ6 integrin is a cell surface adhesion molecule that plays critical roles in the injury and inflammation processes. We hypothesized that polymorphisms in αvβ6 integrin genes (ITGAV and ITGB6) might be associated with the risk of radiation pneumonitis (RP) in lung cancer patients treated with thoracic radiation. We genotyped three potentially functional αvβ6 integrin single-nucleotide polymorphisms (rs1839123 and rs4129787 in ITGAV, and rs4665162 in ITGB6) and found that the genotypes of rs4665162 single-nucleotide polymorphisms were predictors of RP development (for grade ≥2 RP, HR = 1.505, 95 % CI 1.069–2.119, P = 0.019; for grade ≥3 RP, HR = 3.006, 95 % CI 1.431–6.313, P = 0.004). Our results showed that AG/GG genotypes of ITGB6 rs4665162 gene were associated with a higher risk of RP in patients with lung cancer receiving radiotherapy and thus may serve as a reliable predictor of RP. Further studies will be needed to confirm these findings.
KeywordsITGB6 Single-nucleotide polymorphism Radiation pneumonitis Lung cancer
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
This study was funded by National Natural Science Foundation of China (grant numbers 81272492 and 81472921).
Conflicts of interest
Informed consent was obtained from all individual participants included in the study.
- 6.Mak RH, Alexander BM, Asomaning K, Heist RS, Liu C, Su L, et al. A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy. Cancer. 2012;118:3654–65. United States.CrossRefPubMedGoogle Scholar
- 7.Yuan X, Liao Z, Liu Z, Wang L-E, Tucker SL, Mao L, et al. Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. J Clin Oncol. 2009;27:3370–8. United States.CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Shakiba E, Tavilani H, Goodarzi MT, Kiani A, Pourmotabbed T, Vaisi-Raygani A. The ITGAV-rs3911238 polymorphism is associated with disease activity in rheumatoid arthritis. Iran J Allergy Asthma Immunol. 2014;13:356–63. Iran Google Scholar
- 27.Li J, Mu S, Mu L, Zhang X, Pang R, Gao S. Transforming growth factor-beta-1 is a serum biomarker of radiation-induced pneumonitis in esophageal cancer patients treated with thoracic radiotherapy: preliminary results of a prospective study. Onco Targets Ther. 2015;8:1129–36. New Zealand.CrossRefPubMedPubMedCentralGoogle Scholar