Tumor Biology

, Volume 37, Issue 3, pp 3359–3364 | Cite as

Decreased expression of p27 is associated with malignant transformation and extrathyroidal extension in papillary thyroid carcinoma

  • Sung-Im Do
  • Dong Hyun Kim
  • Jung-Ho Yang
  • Jung-Soo Pyo
  • Kyungeun Kim
  • Hyunjoo Lee
  • In-Gu Do
  • Dong-Hoon Kim
  • Seoung Wan Chae
  • Jin Hee Sohn
Original Article


Cell cycle regulatory proteins including p16, p27, and p53 are well studied in various cancers. However, their single or concurrent roles related with the clinicopathological parameters are not clearly recognized. We analyzed the expression of p16, p27, and p53 cell cycle regulatory proteins in papillary thyroid carcinoma (PTC). To determine the prognostic significance of cell cycle regulatory proteins, 107 PTCs were examined. We analyzed the individual expression of p16, p27, and p53 and their concurrent expressions, with the relationship to various clinicopathological parameters including differentiation from benign lesions. High expression of p16 and p53 and low expression of p27 were related with the distinguishing of PTC from benign lesions. In addition, normal thyroidal tissue showed higher p27 expression than nodular hyperplasia. In relation to extrathyroidal extension (ETE), the low expression of p27 was related with the presence of ETE. The low expression of p27 and high expression of p16 and p53 may affect the development of PTC. In addition, low p27 expression is related with the existence of ETE.


Papillary thyroid carcinoma p16 p27 p53 Extrathyroidal extension 


Compliance with ethical standards

Ethical approval

For this type of study, formal consent is not required.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Sung-Im Do
    • 1
  • Dong Hyun Kim
    • 1
  • Jung-Ho Yang
    • 1
  • Jung-Soo Pyo
    • 1
  • Kyungeun Kim
    • 1
  • Hyunjoo Lee
    • 1
  • In-Gu Do
    • 1
  • Dong-Hoon Kim
    • 1
  • Seoung Wan Chae
    • 1
  • Jin Hee Sohn
    • 1
  1. 1.Department of Pathology, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea

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