The emerging role of Nemo-like kinase (NLK) in the regulation of cancers
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Nemo-like kinase (NLK) is an evolutionarily conserved mitogen-activated protein (MAP) kinase-related kinase that is highly expressed in neural tissues and minimally detected in others. Accumulating evidence demonstrates that NLK exerts a pivotal role in cell proliferation, migration, invasion, and apoptosis via regulation of a variety of transcriptional molecules. The results of recent studies have shown that aberrant expression of NLK is significantly associated with the initiation and progression of various types of human cancers, as well as clinicopathologic features and survival rate. NLK is gradually considered as a potential tumor suppressor or an oncogene depending on the tumor system, and silencing or upregulating of NLK may provide an effective therapeutic approach against tumors. In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers.
KeywordsNemo-like kinase Wnt Non-coding RNA Cancer
This project was supported by the National Science Foundation of China (grant nos. 81473268 and 81273526).
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Conflicts of interest
- 18.Han Y. NLK, a novel target of miR-199a-3p, functions as a tumor suppressor in colorectal cancer. Biomed Pharmacother. 2014.Google Scholar
- 23.Kohlhapp FJ. MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene. 2015.Google Scholar
- 29.Zou D. MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK. Tumour Biol. 2015.Google Scholar
- 37.Zhou X. HOTAIR is a therapeutic target in glioblastoma. Oncotarget. 2015.Google Scholar