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Prognostic value of preoperative serum gamma-glutamyltranspeptidase in patients with hepatocellular carcinoma after hepatectomy


Gamma-glutamyltranspeptidase (γ-GGT), an oxidative stress marker, is correlated with inflammation in the extracellular hepatic microenvironment. This study aimed to evaluate the prognostic value of serum γ-GGT levels in patients with hepatocellular carcinoma (HCC) after hepatectomy. Three hundred and eight patients who underwent hepatic resection for HCC were included in the study. Preoperative serum γ-GGT levels, as well as demographic, clinical, and pathologic data, were analyzed. The optimal cutoff value of γ-GGT was 88 U/L. All patients were divided into γ-GGT ≤ 88 U/L group (n = 146) and γ-GGT > 88 U/L group (n = 162). The disease-free survival (DFS) and overall survival (OS) rates of patients in the γ-GGT > 88 U/L group were poorer than those in γ-GGT ≤ 88 U/L group. Preoperative serum γ-GGT levels, associating with gender, HBsAg status, tumor size, capsulation, tumor number, and vascular invasion, was an independent prognostic predictor of disease-free survival [hazard ratio (HR) = 1.616; 95 % confidence interval (CI), 1.223–2.135; P = 0.001] and overall survival (HR = 2.043; 95 % CI, 1.509–2.766; P < 0.001). Furthermore, γ-GGT was also associated with DFS and OS in small HCC (tumor size ≤5 cm) and alpha-fetoprotein (AFP) ≤ 200 ng/mL subgroup. In conclusion, γ-GGT is a promising and reliable prognostic biomarker in HCC patients after hepatic resection, especially for patients with small HCC or AFP ≤ 200 ng/mL.

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This study was supported by the National High Technology Research and Development Program of China (863 Program) (2012AA021007 and 2012AA021008), the Key Clinical Project from the Ministry of Health (2010159), the National Natural Science Foundation of China (81172039, 81373156, and 81471583), the Special Fund for Science Research by Ministry of Health (201302009), and the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Correspondence to Xiaoshun He or Baogang Peng.

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SJF, ZYG, XSH, and BGP were the main authors of the manuscript. They were involved in the conception, design, and coordination of the study as well as in data analysis, interpretation of results, and drafting the manuscript. BGP and XSH were in charge of all experimental procedures. SQL, MK WJH, and YPH participated in the experimental procedures and revised critically the content of the manuscript. All authors contributed to the interpretation of data and critically revised the manuscript. All authors read and approved the final manuscript.

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Shunjun Fu and Zhiyong Guo contributed equally to this work.

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Fu, S., Guo, Z., Li, S. et al. Prognostic value of preoperative serum gamma-glutamyltranspeptidase in patients with hepatocellular carcinoma after hepatectomy. Tumor Biol. 37, 3433–3440 (2016).

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  • γ-Glutamyltranspeptidase
  • Hepatocellular carcinoma
  • Hepatectomy
  • Prognosis