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Tumor Biology

, Volume 37, Issue 3, pp 3025–3031 | Cite as

BMP10 inhibited the growth and migration of gastric cancer cells

  • Haiming Lei
  • Jian Wang
  • Peihua Lu
  • Xinghua Si
  • Koulan Han
  • Tingyan Ruan
  • Junjie Lu
Original Article

Abstract

Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis. Dysregulation of BMP has been observed in several cancer types. However, its roles in gastric cancer (GC) remain unknown. In this study, the expression of BMP10 was found to be down-regulated in GC samples. Forced expression of BMP10 in GC cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. BMP10 was shown to negatively regulated beta-catenin/TCF signaling by up-regulating Axin protein level. Taken together, the present study revealed the suppressive function of BMP10 in gastric cancer.

Keywords

BMP10 Beta-catenin/TCF signaling Axin Cell growth and migration 

Notes

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Haiming Lei
    • 1
  • Jian Wang
    • 2
  • Peihua Lu
    • 3
  • Xinghua Si
    • 1
  • Koulan Han
    • 1
  • Tingyan Ruan
    • 3
  • Junjie Lu
    • 4
  1. 1.Department of Clinical MedicineYancheng Institute of Health SciencesYanchengChina
  2. 2.Department of Gastrointestinal SurgeryHuai’an Hospital Affiliated of Xuzhou Medical College and Huai’an Second People’s HospitalHuai’anChina
  3. 3.Department of Medical OncologyWuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxiChina
  4. 4.Department of Critical Care MedicineAffiliated Yixing People’s Hospital, Jiangsu UniversityYixingChina

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