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RETRACTED ARTICLE: MiR-429 regulates gastric cancer cell invasiveness through ZEB proteins

This article was retracted on 20 April 2017

Abstract

MicroRNAs (miRNAs) play an essential role in the tumorigenesis of gastric carcinoma (GC). MiR-429 has been recently reported to inhibit GC growth; however, whether miR-429 may also regulate the invasion of GC cells is unknown. Here, we showed that miR-429 levels were significantly decreased and ZEB1 and ZEB2 levels were significantly increased in GC specimens, compared to the paired adjacent non-tumor gastric tissue. Moreover, the levels of miR-429 and ZEB1 or ZEB2 inversely correlated in GC specimens. Bioinformatics analyses showed that miR-429 targeted the 3′-untranslated region of both ZEB1 and ZEB2 mRNA to inhibit their translation, which was confirmed by luciferase reporter assay. Overexpression of miR-429 inhibited ZEB1/2-mediated cell invasiveness, while depletion of miR-429 augmented it. Together, our data suggest that miR-429 suppression in GC promotes ZEB1/2-mediated cancer cell invasion.

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Correspondence to Huichi Hou.

Ethics declarations

Prior patient’s consents and approval from the Institutional Research Ethics Committee of the Bethune International Peace Hospital were obtained for this study.

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None

Additional information

Wei Liu and Jie An contributed equally to this work.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Liu, W., An, J., Li, K. et al. RETRACTED ARTICLE: MiR-429 regulates gastric cancer cell invasiveness through ZEB proteins. Tumor Biol. 37, 15575–15581 (2016). https://doi.org/10.1007/s13277-015-4094-7

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  • DOI: https://doi.org/10.1007/s13277-015-4094-7

Keywords

  • Gastric carcinoma (GC)
  • ZEB1
  • ZEB2
  • miR-429