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Tumor Biology

, Volume 37, Issue 2, pp 2435–2441 | Cite as

Propensity score-based comparison of hepatic resection and transarterial chemoembolization for patients with advanced hepatocellular carcinoma

Original Article

Abstract

For patients with advanced hepatocellular carcinoma (HCC), official guidelines recommend palliative treatments such as transarterial chemoembolization (TACE) but not hepatic resection (HR). This study compared short- and long-term outcomes in patients with advanced HCC treated by either HR or TACE. A retrospective analysis was performed for a consecutive series of 444 patients with advanced HCC who underwent HR (n = 339) or TACE (n = 205). Analyses were performed over all participants as well as for propensity score-matched patients to adjust for any baseline differences. When all patients were included in the analysis, the HR and TACE groups showed similar postoperative complication rate and mortality at 30 and 90 days (all P > 0.05). However, median survival time was significantly higher in the HR group (16.4 months) than in the TACE group (11.8 months; P = 0.012). Overall survival at 1, 3, 5, and 7 years was 58, 26, 18, and 18 % in the HR group, higher than the corresponding rates of 49, 14, 12, and 7 % in the TACE group. Similar results were obtained in the analysis of propensity score-matched patients. Therefore, HR can be safe and effective for patients with advanced HCC. Randomized controlled trials are warranted to confirm this finding.

Keywords

Hepatocellular carcinoma Hepatic resection Overall survival Transarterial chemoembolization 

Abbreviations

AFP

α-Fetoprotein

HCC

Hepatocellular carcinoma

HR

Hepatic resection

OS

Overall survival

PVTT

Portal vein tumor thrombus

TACE

Transarterial chemoembolization

Notes

Acknowledgments

The authors thank A. Chapin Rodríguez, PhD, for his language editing, which substantially improved the quality of the manuscript. This work was supported by the National Science and Technology Major Special Project of the Ministry of Science and Technology of China (2012ZX10002010001009), the National Natural Science Foundation of China (81260331, 81160262, 81560460), the Guangxi University of Science and Technology Research Projects (KY2015LX056), the Self-Raised Scientific Research Fund of the Ministry of Health of Guangxi Province (Z2015621, GZZC15-34, Z2014241), and the Innovation Project of Guangxi Graduate Education (YCBZ2015030).

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Bao-Hong Yuan
    • 1
  • Wei-Ping Yuan
    • 2
  • Ru-Hong Li
    • 1
  • Bang-De Xiang
    • 2
  • Wen Feng Gong
    • 2
  • Le-Qun Li
    • 2
  • Jian-Hong Zhong
    • 2
  1. 1.Department of General SurgeryYan’An Hospital Affiliated to Kunming Medical UniversityKunmingPeople’s Republic of China
  2. 2.Hepatobiliary Surgery DepartmentAffiliated Tumor Hospital of Guangxi Medical UniversityNanningPeople’s Republic of China

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