Tumor Biology

, Volume 37, Issue 2, pp 2621–2627 | Cite as

HEPACAM inhibited the growth and migration of cancer cells in the progression of non-small cell lung cancer

  • Huanzhang Shao
  • Yinjie Gu
  • Junli Ding
  • Peihua Lu
  • Tingyan Ruan
  • Wenbin Lu
Original Article

Abstract

Hepatocyte cell adhesion molecule (HEPACAM), a member of immunoglobulin superfamily, is an adhesion molecule. Although dysregulation of several adhesion molecules has been implicated in the progression of non-small cell lung cancer (NSCLC), the expression profile and functions of HEPACAM in NSCLC remains unknown. In this study, it was found that the expression of HEPACAM was downregulated in NSCLC tissues. Forced expression of HEPACAM in NSCLC cells inhibited the growth and migration of the cancer cells, while knocking down the expression of HEPACAM promoted cell growth, migration, and metastasis. In the molecular mechanism study, HEPACAM was found to be a negative regulator of beta-catenin/TCF signaling. Taken together, this study revealed the suppressive roles of HEPACAM in NSCLC and restoring the function of HEPACAM in NSCLC might be a promising strategy for the therapy.

Keywords

HEPACAM Non-small cell lung cancer Cell growth and migration Beta-catenin/TCF 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Huanzhang Shao
    • 1
  • Yinjie Gu
    • 2
  • Junli Ding
    • 3
  • Peihua Lu
    • 3
  • Tingyan Ruan
    • 3
  • Wenbin Lu
    • 4
  1. 1.Department of Critical Care Medicine, Henan Provincial People’s HospitalAffiliated of Zhengzhou UniversityZhengzhouChina
  2. 2.Department of Critical Care Medicine, Affiliated Yixing People’s HospitalJiangsu UniversityYixingChina
  3. 3.Department of Medical OncologyWuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxiChina
  4. 4.Department of Medical OncologyWujin People’s Hospital Affiliated to Jiangsu UniversityChangzhouChina

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