Tumor Biology

, Volume 37, Issue 2, pp 2443–2448 | Cite as

Identification of a shared protective genetic susceptibility locus for colorectal cancer and gastric cancer

Original Article
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Abstract

Risk of both colorectal cancer (CRC) and gastric cancer (GC) is considered to be heritable with mounting evidence for their genetic susceptibility. However, it remains unknown whether a shared genetic background is underlying these two cancers. A total of ten single nucleotide polymorphisms (SNPs) associated with digestive system cancers risk were selected from previous genome-wide association studies. All SNPs were genotyped in 449 CRC cases, 588 GC cases, and 703 controls using Sequenom Mass-ARRAY technology. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were estimated using unconditional logistic regression analysis with adjustment for age and gender, and evaluated their association with both cancers in a Han Chinese population using chi-squared (χ 2) test and genetic model analysis. By χ 2 test, we found that rs2057314 (p = 0.028; OR = 1.21) was significantly associated with an increased risk of CRC, rs7758229 (p = 0.005; OR = 0.77) was significantly associated with a decreased risk of GC. Furthermore, a shared susceptibility locus rs9502893 was found to have significant protective effect against CRC (p = 0.010; OR = 0.80) and GC (p = 0.0003; OR = 0.74). Our findings could provide insight into the underlying shared a partly overlapping genetic aspect of CRC and GC in a Chinese population. Additional studies are required to verify and discover more common genetic variants associated with risk for digestive system cancers.

Keywords

Colorectal cancer Gastric cancer Single nucleotide polymorphism Susceptibility 

Notes

Acknowledgments

This work is supported by the Key Program of Natural Science Foundation of Xizang (Tibet) Autonomous Region (20152R-13-11) and Major Training Program of Tibet University for Nationalities (No. 13myZP06).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of MedicineXizang Minzu UniversityXianyangChina
  2. 2.Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of MedicineXizang Minzu UniversityXianyangChina
  3. 3.Department of General Surgery, People’s Hospital of Shaanxi ProvinceXi’anChina
  4. 4.School of Life SciencesNorthwest UniversityXi’anChina

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