Tumor Biology

, Volume 37, Issue 2, pp 2177–2181 | Cite as

Low 25-OH vitamin D levels at time of diagnosis and recurrence of ovarian cancer

  • Teresa Granato
  • Lucia Manganaro
  • Luca Petri
  • Maria Grazia Porpora
  • Valentina Viggiani
  • Antonio Angeloni
  • Emanuela Anastasi
Original Article


The objective of this study was to evaluate the correlation between 25-OH vitamin D and ovarian cancer as a diagnostic marker or recurrence disease marker. We studied the following: (1) 61 women without gynecologic diseases, (2) 45 women affected by benign ovarian disease, (3) 46 women with recent diagnosis of ovarian cancer, (4) 26 follow-up women with recurrent ovarian cancer, and (5) 32 follow-up women with stable ovarian cancer. The 25-OH vitamin D was quantified with LUMIPULSE® G 25-OH vitamin D on LUMIPULSE® G 1200 (Fujirebio, Japan). As a threshold value, identified by ROC curve analysis, 20.2 ng/mL (sensitivity 73.3 %, specificity 84 %) was chosen corresponding to the limit between sufficient and insufficient 25-OH vitamin D according to the WHO. Low 25-OH vitamin D levels were observed in 26 % of women without gynecologic diseases, in 80 % of women with recent diagnosis of ovarian cancer and in 24 % women affected by benign ovarian diseases (p < 0.001). The follow-up study showed an insufficient level of 25-OH vitamin D in 73 % women with recurrent ovarian cancer and in 47 % women with stable ovarian cancer (p < 0.0003). This study showed that patients with ovarian cancer are often insufficient in 25-OH vitamin D compared to women with benign ovarian diseases. The women with recurrent ovarian cancer presented more often low levels compared to women with stable ovarian cancer. This study suggests that 25-OH vitamin D, due to its antiproliferative properties, can be a good marker for ovarian cancer also.


25-OH vitamin D Biomarker Epithelial ovarian cancer Follow-up 



This study is founded by the University of Rome Sapienza. The authors are thankful to Giuseppina Gennarini, Barbara Colaprisca, and Silvestra Tudini for their excellent technical assistance.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Teresa Granato
    • 1
  • Lucia Manganaro
    • 2
  • Luca Petri
    • 3
  • Maria Grazia Porpora
    • 4
  • Valentina Viggiani
    • 3
  • Antonio Angeloni
    • 3
  • Emanuela Anastasi
    • 3
  1. 1.CNR-IBPM, National Research CouncilRomeItaly
  2. 2.Department of Radiological, Oncological, and Pathological Sciences“Sapienza” University of RomeRomeItaly
  3. 3.Department of Molecular Medicine“Sapienza” University of RomeRomeItaly
  4. 4.Department of Gynecology, Obstetrics and Urology“Sapienza” University of RomeRomeItaly

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