Tumor Biology

, Volume 37, Issue 2, pp 2765–2771 | Cite as

MicroRNA-346 functions as an oncogene in cutaneous squamous cell carcinoma

  • Bin Chen
  • Wenyan Pan
  • Xiaoxi Lin
  • Zhenzhen Hu
  • Yunbo Jin
  • Hui Chen
  • Gang Ma
  • Yajing Qiu
  • Lei Chang
  • Chen Hua
  • Yun Zou
  • Yang Gao
  • Hanru Ying
  • Dongze Lv
Original Article

Abstract

Cutaneous squamous cell carcinoma (cSCC) is an epidermal keratinocyte-derived skin tumor, which is the second most common skin cancer in the general population. Recently, studies showed that microRNAs (miRNAs) played an important role in the development of cancer. In our study, we showed that the expression of SRCIN1 was lower in cSCC tissues than in the matched normal tissues. Moreover, there was significant inversed correlation between miR-346 and SRCIN1 in cSCC tissues. The luciferase reporter assay data showed that miR-346 can target the SRCIN1 message via the 3′-untranslated region (UTR) of SRCIN1. Overexpression of miR-346 inhibited the messenger RNA (mRNA) and protein expression of SRCIN1 in the A431 cells. In addition, ectopic expression of miR-346 promoted the A431 cell proliferation and migration. Meanwhile, SRCIN1 overexpression inhibited the A431 cell proliferation and migration. Rescue experiment has showed that SRCIN1 overexpression reduced the miR-346-induced A431 cell proliferation and migration. Herein, this study may provide miR-346 as a new therapeutic target for cSCC.

Keywords

Cutaneous squamous cell carcinoma miR-346 SRCIN1 Oncogene 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Bin Chen
    • 1
    • 2
  • Wenyan Pan
    • 3
  • Xiaoxi Lin
    • 1
  • Zhenzhen Hu
    • 4
  • Yunbo Jin
    • 1
  • Hui Chen
    • 1
  • Gang Ma
    • 1
  • Yajing Qiu
    • 1
  • Lei Chang
    • 1
  • Chen Hua
    • 1
  • Yun Zou
    • 1
  • Yang Gao
    • 1
  • Hanru Ying
    • 1
  • Dongze Lv
    • 1
  1. 1.Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of MedicineShanghai Jiao Tong UniversityShanghaiChina
  2. 2.Department of Plastic and Reconstructive Surgery, Liuzhou Worker’s HospitalThe Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhouChina
  3. 3.Department of Neurosurgery, Liuzhou Worker’s HospitalThe Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhouChina
  4. 4.Department of Plastic Surgery, Zhujiang HospitalSouthern Medical UniversityGuangzhouChina

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