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Tumor Biology

, Volume 37, Issue 2, pp 2095–2103 | Cite as

MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo

  • Qi-guang Chen
  • Wei Zhou
  • Tao Han
  • Shu-qi Du
  • Zhen-hua Li
  • Zhe Zhang
  • Guang-yi Shan
  • Chui-ze Kong
Original Article

Abstract

Prostate cancer is one of the biggest health problems for the aging male. To the present, the roles of dysregulated microRNAs in prostate cancer are still unclear. Here, we evaluated the anti-proliferative role of miR-378 in prostate cancer. And, we found that the expression of miR-378 was significantly downregulated in clinical prostate cancer tissues. In vitro assay suggested that overexpression of miR-378-suppressed prostate cancer cell migration and invasion promoted cell apoptosis. Furthermore, we identified and validated MAPK1 as a direct target of miR-378. Ectopic expression of MAPK1 rescues miR-378-suppressed cell migration and invasion. In vivo assay demonstrated that the stably miR-378-overexpressed prostate cancer cells displayed a significantly reduction in tumor growth. Taken together, our data suggested that miR-378 may act as a potential therapeutic target against human prostate cancer.

Keywords

Prostate cancer microRNA miR-378 MAPK1 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Qi-guang Chen
    • 1
  • Wei Zhou
    • 2
  • Tao Han
    • 3
  • Shu-qi Du
    • 1
  • Zhen-hua Li
    • 1
  • Zhe Zhang
    • 1
  • Guang-yi Shan
    • 4
  • Chui-ze Kong
    • 1
  1. 1.Department of UrologyThe First Affiliated Hospital of China Medical UniversityShenyangChina
  2. 2.Department of Diagnostic RadiologyGeneral Hospital of Shenyang Military RegionShenyangChina
  3. 3.Department of OncologyGeneral Hospital of Shenyang Military RegionShenyangChina
  4. 4.Department of UrologyLiaoNing Cancer Hospital and InstituteShenyangChina

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