Tumor Biology

, Volume 37, Issue 2, pp 2067–2074 | Cite as

Association of intercellular adhesion molecule-1 single nucleotide polymorphisms with hepatocellular carcinoma susceptibility and clinicopathologic development

  • Tsung-Po Chen
  • Hsiang-Lin Lee
  • Yu-Hui Huang
  • Ming-Ju Hsieh
  • Whei-Ling Chiang
  • Wu-Hsien Kuo
  • Ming-Chih Chou
  • Shun-Fa Yang
  • Chao-Bin Yeh
Original Article


Intercellular adhesion molecule-1 (ICAM-1) is a human protein encoded by the ICAM-1 gene and is typically expressed on endothelial cells and immune cells. ICAM-1 is associated with episode, growth, invasion, and metastasis of hepatocellular carcinoma (HCC). However, the association between ICAM-1 genetic variants and the risk of HCC is undetermined. In this study, we investigated the potential associations of ICAM-1 single nucleotide polymorphisms (SNPs) with susceptibility to HCC and its clinicopathological characteristics. A total of 918 participants, including 613 controls participants and 305 patients with HCC, were selected for the analysis of ICAM-1 SNPs (rs3093030, rs5491, rs281432, and rs5498) by using real-time PCR genotyping. After adjusting for covariants of age, sex, and alcohol consumption, 125 smoker patients with HCC carrying at least one G genotype (AG and GG) in rs5498 were observed to have a higher HCC risk compared with 231 smoker control participants carrying the wild-type allele AA (adjusted odds ratio (AOR), 1.713; 95 % confidence interval (CI), 1.091–2.690; P = 0.019). However, patients who possess at least one polymorphic allele of rs5498 are less prone to develop vascular invasive (AOR, 0.309; 95 % CI, 0.103–0.926; P = 0.036). The results suggest that the genetic polymorphism in ICAM-1 rs5498 SNPs with genotype AG and GG is associated with HCC risk among smokers. Moreover, gene and environment interactions of ICAM-1 rs5498 polymorphisms might alter susceptibility to liver cancer. Therefore, ICAM-1 rs5498 may serve as a marker to predict the vascular invasion risk in smoker patients with HCC.


Hepatocellular carcinoma Intercellular adhesion molecule-1 Single nucleotide polymorphisms 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Tsung-Po Chen
    • 1
  • Hsiang-Lin Lee
    • 1
    • 2
  • Yu-Hui Huang
    • 3
    • 4
  • Ming-Ju Hsieh
    • 1
    • 5
  • Whei-Ling Chiang
    • 6
  • Wu-Hsien Kuo
    • 7
  • Ming-Chih Chou
    • 1
  • Shun-Fa Yang
    • 1
    • 8
  • Chao-Bin Yeh
    • 9
    • 10
  1. 1.Institute of MedicineChung Shan Medical UniversityTaichungTaiwan
  2. 2.Department of SurgeryChung Shan Medical University HospitalTaichungTaiwan
  3. 3.School of MedicineChung Shan Medical UniversityTaichungTaiwan
  4. 4.Department of Physical Medicine and RehabilitationChung Shan Medical University HospitalTaichungTaiwan
  5. 5.Cancer Research CenterChanghua Christian HospitalChanghuaTaiwan
  6. 6.School of Medical Laboratory and BiotechnologyChung Shan Medical UniversityTaichungTaiwan
  7. 7.Division of Gastroenterology, Department of Internal MedicineKaohsiung Armed Forces General HospitalKaohsiungTaiwan
  8. 8.Department of Medical ResearchChung Shan Medical University HospitalTaichungTaiwan
  9. 9.Department of Emergency Medicine, School of MedicineChung Shan Medical UniversityTaichungTaiwan
  10. 10.Department of Emergency MedicineChung Shan Medical University HospitalTaichungTaiwan

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