Circulating CD105 shows significant impact in patients of oral cancer and promotes malignancy of cancer cells via CCL20
CD105 is rich in endothelium cells and is involved in angiogenesis. Higher microvascular density of tumor is also related to the prognosis in a variety of cancers. In this present study, patients with positive N classification, advanced T classification, advanced TNM stage, extracapsular spread of lymph nodes (ECS), and perineural invasion had significantly higher levels of peripheral vein (pCD105) and venous return from tumor (tCD105) in 71 patients with OSCC compared to 13 healthy volunteers. Those with higher pCD105 or tCD105 levels had significantly poorer 5-year disease-specific survival rate (DDS) and overall survival rate (OS). The tCD105 and pCD105 levels and ECS were the independent prognostic factors by the multivariate analysis according to the Cox regression model in 5-year DDS and OS rate. SAS and SCC4 cells treated with CD105 showed the increase in migration, invasion, and proliferation in vitro and in vivo. Furthermore, CCL20 expression participated in CD105-elicited cell motility in oral cancer cells. In conclusion, higher level of circulating CD105 is related to adverse pathological features among patients with OSCC. It is also a useful marker for evaluating the prognosis and targeting therapeutics of OSCC.
KeywordsCD105 Endoglin Metastasis Oral cancer Prognosis
This study was supported in part by grants CMRPG890091-3, CMRPG8B0971-2, CMRPG8D1421, CMRPG890921, CMRPG8A0391-2, CMRPG8C0591-2, CMRPG8B1251-3, CMRPG8C0581-2, and CMRPG8B1451 from the Chang Gung Memorial Hospital and the grants MOST-98-2314-B-182A-042-MY3, MSOT-101-2314-B-182A-043-MY3, MOST-104-2314-B-182A-075-MY3, MOST-103-2320-B-182A-015-, and MOST-104-2320-B-182A-010- from the Ministry of Science and Technology of Taiwan. We would also like to thank the Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital Tissue Bank (CLRPG870463) for technical support.
Conflict of interest
The authors declare no conflict of interest.
Chang-Han Chen, Hui-Ching Chuang, Yu-Tsai Lin, and Chih-Yen Chien collected the clinical data of patients, conceived the study design, carried out and coordinated immunohistochemical examinations of tumor specimens and data analysis, and drafted the manuscript. Fu-Min Fang and Hui Lu performed statistical data analysis. Chao-Cheng Huang participated in the interpretation of data and conducted immunohistochemistry analysis. Ching-Mei Chen carried out immunohistochemical examinations of tumor specimens.
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