Tumor Biology

, Volume 37, Issue 2, pp 2075–2081 | Cite as

Lipase member H frequently overexpressed in human esophageal adenocarcinomas

  • Hisako Ishimine
  • Rui Zhou
  • Kenya Sumitomo
  • Yoshimasa Ito
  • Yasuhiro Seki
  • Yukihiro Yoshida
  • Akira Kurisaki
Original Article


Esophageal cancer is one of the most frequent causes of cancer-related deaths worldwide. This is due to its asymptomatic nature or mild nonspecific symptoms. Most patients are diagnosed after appearance of prominent symptoms, and tumors are frequently accompanied by severe infiltration. Therefore, molecular biomarkers for the prognosis of early-stage esophageal cancer are desired. In this study, we examined the prognostic potential of lipase H (LIPH), a recently reported biomarker for lung adenocarcinoma and squamous carcinoma. We found that LIPH mRNA is also frequently upregulated in esophageal adenocarcinoma. Immunohistochemical analysis confirmed LIPH protein expression in various esophageal tumor tissue sections. Interestingly, higher expression of LIPH in esophageal adenocarcinoma showed a positive correlation with longer survival of patients. Our data suggest that LIPH may have prognostic value for esophageal cancer.


Lipase member H Prognostic marker Esophageal adenocarcinoma Esophageal squamous cell carcinoma 



The esophageal adenocarcinoma cell line (KYAE-1) was obtained from JCRB Cell Bank. SK-GT-2 and SK-GT-4 cell lines were obtained from the Public Health England. Dr. Rui Zhou is supported as an International Research Fellow of the Japan Society for the Promotion of Science.

Conflicts of interest

The authors declare conflict of interest as they have filed a PCT patent application for the potential marker of LIPH (PCT Patent Application No. PCT/JP2014/058147).


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Hisako Ishimine
    • 1
  • Rui Zhou
    • 1
    • 2
  • Kenya Sumitomo
    • 3
  • Yoshimasa Ito
    • 1
  • Yasuhiro Seki
    • 1
  • Yukihiro Yoshida
    • 4
  • Akira Kurisaki
    • 1
    • 5
  1. 1.Research Center for Stem Cell EngineeringNational Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan
  2. 2.Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular ResearchSichuan Medical UniversityLuzhouChina
  3. 3.Department of Internal MedicineJA Kochi HospitalKochiJapan
  4. 4.Department of SurgeryAsahi General HospitalChibaJapan
  5. 5.Graduate School of Life and Environmental SciencesThe University of TsukubaTsukubaJapan

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