Caveolin-1 overexpression in benign and malignant salivary gland tumors
- 186 Downloads
Caveolin-1, a tyrosine-phosphorylated protein, is supposed to have different regulatory roles as promoter or suppressor in many human cancers. However, no published study concerned its expression in benign and malignant salivary gland tumors. The aim of this study was to evaluate and compare the expression of Cav-1 in the most common benign and malignant salivary gland tumors and evaluate its correlation with proliferation activity. In this cross-sectional retrospective study, immunohistochemical expression of caveolin-1 and Ki67 were evaluated in 49 samples, including 11 normal salivary glands, 15 cases of pleomorphic adenoma (PA), 13 adenoid cystic carcinomas (AdCC), and 10 mucoepidermoid carcinomas (MEC). The expression of Cav-1 was seen in 18 % of normal salivary glands and 85 % of tumors. The immunoreaction in the tumors was significantly higher than normal tissues (P = 0.001), but the difference between benign and malignant tumors was not significant (P = 0.07). Expression of Cav-1 was correlated with Ki67 labeling index in PAs, but not in malignant tumors. Cav-1 expression was not in association with tumor size and stage. Overexpression of Cav-1 was found in salivary gland tumors in comparison with normal tissues, but no significant difference was observed between benign and malignant tumors. Cav-1 was inversely correlated with proliferation in PA. Therefore, this marker may participate in tumorigenesis of salivary gland tumors and may be a potential biomarker for cancer treatments.
KeywordsSalivary gland tumor Caveolin-1 Ki67 Pleomorphic adenoma Adenoid cystic carcinoma Mucoepidermoid carcinoma
The authors thank the Vice-Chancellery of Shiraz University of Medical Science for supporting this research (Grant No. 92-01-03-6272). The authors would like to thank Dr. Sh. Hamedani (DDS, MSc) for helping with the English and editorial assistance in the manuscript and Dr. M. Vossoughi from the Dental Research Development Centre for the statistical analysis. This manuscript is related to the undergraduate thesis of Z. Azizi (Shiraz University of Medical Science, Shiraz, Iran).
- 19.Savage K, Lambros MB, Robertson D, Jones RL, Jones C, Mackay A, et al. Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis. Clin Cancer Res. 2007;13(1):90–101.CrossRefPubMedGoogle Scholar
- 26.Rathor N, Chung HK, Wang SR, Wang JY, Turner DJ, Rao JN. Caveolin-1 enhances rapid mucosal restitution by activating TRPC1-mediated Ca2+ signaling. Physiol Rep. 2014;3:2(11).Google Scholar
- 34.Schwab W, Harada H, Goetz W, Nowicki M, Witt M, Kasper M, et al. Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells. Histochem Cell Biol. 2007;128(3):195–203.CrossRefPubMedGoogle Scholar