Tumor Biology

, Volume 37, Issue 12, pp 15559–15566 | Cite as

RETRACTED ARTICLE: Effects of radiotherapy on nasopharyngeal carcinoma cell invasiveness

  • Zheng Peng
  • Tiancai Xu
  • Xiaofang Liao
  • Huijuan He
  • Wansu Xu
Original Article
  • 815 Downloads

Abstract

Radiotherapy is widely used in the treatment of nasopharyngeal carcinoma (NPC), whereas its effects on the NPC growth, survival, and metastases have not been completely evaluated. Here, we compared the detected metastatic NPC tissues after radiotherapy (m-NPC) to the resected primary NPC tissues prior to radiotherapy (p-NPC). We detected higher levels of Snail2 protein, but not mRNA in m-NPC, compared to p-NPC. In vitro, a modest irradiation on NPC cells resulted in significant cell death, but increased Snail2 protein, but mRNA levels in the surviving NPC cells. Bioinformatics analyses showed that miR-613, which was significantly decreased in NPC cells after irradiation, targeted the 3′-UTR of Snail2 mRNA to inhibit its translation. Moreover, miR-613 overexpression inhibited Snail2-mediated cell invasiveness, while miR-613 depletion increased Snail2-mediated cell invasiveness in NPC cells. Finally, we detected significantly lower levels of miR-613 in m-NPC, compared to p-NPC. Together our data suggest that although radiotherapy induced NPC cell death, it may increase Snail2-mediated NPC cell invasiveness through downregulating miR-613.

Keywords

Nasopharyngeal carcinoma (NPC) Radiotherapy Snail2 miR-613 

Notes

Conflict of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Zheng Peng
    • 1
  • Tiancai Xu
    • 1
  • Xiaofang Liao
    • 1
  • Huijuan He
    • 1
  • Wansu Xu
    • 1
  1. 1.Department of Radiation OncologyQuzhou People HospitalQuzhouChina

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