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Tumor Biology

, Volume 37, Issue 2, pp 1797–1801 | Cite as

In situ dendritic cell vaccination for the treatment of glioma and literature review

  • Ming Li
  • Shuangyin Han
  • Xiwen Shi
Original Article

Abstract

Glioma is one of the greatest threats to human health, and invasive growth of glioma is its major cause of death. Inhibiting or blocking angiogenesis can effectively inhibit tumor growth and metastasis or dramatically reduce the size of the original lesion. Therefore, anti-angiogenic therapy has currently become the most promising treatment strategy for glioma. Although dendritic cells (DCs) used in DC-based immunotherapy are loaded with tumor-associated antigens, the anti-tumor immune response is effectively stimulated in cytotoxic specific T lymphocytes (CTLs), thereby achieving targeted killing of tumor cells without harming surrounding normal cells. This makes it a highly promising new form of therapy. This article reviews the existing evidence regarding in situ DC vaccination for the treatment of glioma and puts forward hypotheses regarding patient, tumor, and technical factors and warrant further investigation.

Keywords

Chitosan nanoparticles Dendritic cells Glioma Vaccination 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of NeurosurgeryThe People’s Hospital of Zhengzhou UniversityZhengzhou CityPeople’s Republic of China

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