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Tumor Biology

, Volume 37, Issue 2, pp 1635–1639 | Cite as

Evaluation of GWAS-identified SNPs at 6p22 with neuroblastoma susceptibility in a Chinese population

  • Jing He
  • Ruizhong Zhang
  • Yan Zou
  • Jinhong Zhu
  • Tianyou Yang
  • Fenghua Wang
  • Huimin Xia
Original Article

Abstract

Previous genome-wide association studies (GWASs) have reported that three single nucleotide polymorphisms (SNPs) (rs6939340 A>G, rs4712653 T>C, and rs9295536 C>A) located at 6p22 locus were associated with neuroblastoma susceptibility for Caucasian descent. We conducted this hospital-based case-control study with 201 neuroblastoma patients and 531 controls to investigate the association between these three SNPs in the FLJ22536 gene with neuroblastoma susceptibility in the Chinese Han population. The odds ratio (OR) and 95 % confidence interval (CI) were calculated to estimate the strength of the association using unconditional logistic regression model. We found that the rs6939340 A allele carriers were associated with significantly decreased neuroblastoma susceptibility (AG vs. GG: adjusted OR = 0.54, 95 % CI = 0.38–0.77; AA vs. GG: adjusted OR = 0.49, 95 % CI = 0.25–0.93; and AA/AG vs. GG: adjusted OR = 0.53, 95 % CI = 0.38–0.74) after adjustment for age and gender. The protective association between variant allele and neuroblastoma susceptibility was also observed for the rs4712653 and rs9295536 polymorphisms. Moreover, we found that subjects carrying one or more protective genotypes had a much lower neuroblastoma susceptibility than non-carriers (adjusted OR = 0.60, 95 % CI = 0.43–0.83). Our study verified that the associations between all of the three SNPs in the 6p22 locus are associated with neuroblastoma susceptibility in the Chinese subjects. Further prospective multicenter studies with different ethnicities and larger sample size are needed to validate our findings.

Keywords

GWAS 6p22 Polymorphism Neuroblastoma Susceptibility 

Notes

Acknowledgments

This work was supported by the grant of State Clinical Key Specialty Construction Project (Pediatric Surgery) 2013, No: GJLCZD1301.

Conflicts of interest

The authors declare no conflicts of interest.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Jing He
    • 1
  • Ruizhong Zhang
    • 1
  • Yan Zou
    • 1
  • Jinhong Zhu
    • 2
  • Tianyou Yang
    • 1
  • Fenghua Wang
    • 1
  • Huimin Xia
    • 1
  1. 1.Department of Pediatric Surgery, Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina
  2. 2.Molecular Epidemiology Laboratory and Department of Laboratory MedicineHarbin Medical University Cancer HospitalHarbinChina

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