PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma
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Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignancies in the world. Numerous studies have linked the activation of AKT to the progression of PDAC. Phosphatidylethanolamine-binding protein 4 (PEBP4) has been reported to be upregulated in various cancer types. However, its expression pattern and biological functions in PDAC are unknown. In this study, it was found that the messenger RNA (mRNA) and protein level of PEBP4 was elevated in PDAC samples. Forced expression of PEBP4 in PDAC cell lines promoted cell growth and migration, while downregulation of PEBP4 in PDAC cells by RNA interference (RNAi) inhibited the growth, migration, and metastasis of the cancer cells. PEBP4 interacted with AKT and promoted the phosphorylation of serine 473 in AKT. Collectively, this study suggested that PEBP4 might promote the progression of PDAC through activating AKT signaling and PEBP4 might be a promising therapeutic target for PDAC treatment.
KeywordsPEBP4 PDAC AKT Cell growth and migration
This work was supported by the findings from the National Natural Science Foundation of China (81272728), Shanghai Municipal Commission of Health and Family Planning (201440338), Shanghai Minhang District Commission of Science and Technology (2014MW22), and Shanghai Minhang District Commission of Science and Technology (2011MHZ06, 2011MHZ25).
Conflicts of interest