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MicroRNA-224: as a potential target for miR-based therapy of cancer

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Tumor Biology

Abstract

MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (81272470).

Conflicts of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, China

    Wei Chen

  2. Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China

    Wei Chen, Jun-ying Zhang, Jian LI, Jian-zhong Wu & Jin-hai Tang

  3. Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China

    Xue-mei Fan

  4. Department of General Surgery, Huaian Second People’s Hospital, Huaian, China

    Ling Mao

  5. Department of General Surgery, The Affiliated Jiangsu Cancer Hospital, Nanjing Medical University, 42Bai Zi Ting Road, Nanjing, Jiangsu, 210000, China

    Jin-hai Tang

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  1. Wei Chen
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  2. Xue-mei Fan
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  3. Ling Mao
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  4. Jun-ying Zhang
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Correspondence to Jin-hai Tang.

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Chen, W., Fan, Xm., Mao, L. et al. MicroRNA-224: as a potential target for miR-based therapy of cancer. Tumor Biol. 36, 6645–6652 (2015). https://doi.org/10.1007/s13277-015-3883-3

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  • DOI: https://doi.org/10.1007/s13277-015-3883-3

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