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Tumor Biology

, Volume 37, Issue 1, pp 823–828 | Cite as

RETRACTED ARTICLE: The critical role of HMGA2 in regulation of EMT in epithelial ovarian carcinomas

  • Junyuan Yan
  • Yanling Zhang
  • Wenshuang Shi
  • Cuili Ren
  • Yan Liu
  • Yunyan Pan
Original Article

Abstract

The high mobility group A2 (HMGA2), an oncofetal protein, was shown to play a role in tumor development and progression. However, the molecular and clinical role of HMGA2 in epithelial ovarian carcinomas (EOCs) is still unknown. In the present study, EOC cell line SKOV3 was subjected to in vitro assays. Here, our findings showed that HMGA2 was highly expressed in EOC cell line SKOV3. HMGA2 knockdown promoted cell apoptosis and the cleavage of caspase 3, and decreased the B cell lymphoma 2 (Bcl-2)/Bax ratio in SKOV3. Functionally, HMGA2 knockdown resulted in reduction of SKOV3 cell migration and invasion. Mechanically, HMGA2 knockdown affected the occurrence of EMT by increasing E-cadherin gene and protein expression and decreasing the gene and protein expression of N-cadherin, slug, and vimentin. At the same time, HMGA2 also repressed the expression of matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9), which was consistent with the decreased invasion capacity. In conclusion, HMGA2 is associated with migration and invasiveness and regulates the progression of EMT in the development of EOC, and HMGA2 gene and protein may be a novel therapeutic target against EOC in the clinical practice.

Keywords

HMGA2 Epithelial ovarian carcinomas EMT 

Notes

Acknowledgments

We greatly thank other members of Yang Lab for valuable suggestions and writing.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Junyuan Yan
    • 1
  • Yanling Zhang
    • 2
  • Wenshuang Shi
    • 2
  • Cuili Ren
    • 2
  • Yan Liu
    • 1
  • Yunyan Pan
    • 1
  1. 1.Department of Gynaecology and ObstetricsAffiliated Hospital of Shandong Academy of Medical SciencesJinanChina
  2. 2.Department of Gynaecology and ObstetricsThe Third People’s Hospital of Jinan CityJinanChina

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