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RETRACTED ARTICLE: MiR-200 suppresses metastases of colorectal cancer through ZEB1

Tumor Biology volume 37, pages 15501–15507 (2016)Cite this article

This article was retracted on 20 April 2017

Abstract

Poor prognosis of some colorectal cancer (CRC) cases largely results from early metastases of CRC to the distal organs. Thus, suppression of the invasion of CRC appears to be crucial therapy. Since microRNAs (miRNAs) play critical roles in the regulation of cancer metastases, identification of the involved miRNAs may provide novel therapeutic targets for CRC treatment. Here, we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients, compared to the paired non-tumor tissue. Moreover, the levels of miR-200 and ZEB1 are inversely correlated. Bioinformatics analyses showed that miR-200 targeted the 3′-UTR of ZEB1 mRNA to inhibit its translation, which was confirmed by luciferase reporter assay. Moreover, miR-200 overexpression inhibited ZEB1-mediated cell invasiveness, while miR-200 depletion increased ZEB1-mediated cell invasiveness in CRC cells. Together, our data suggest that miR-200 suppression in CRC cells may promote ZEB1-mediated cancer metastasis. Our work thus highlights a novel molecular regulatory machinery that regulates metastases of CRC.

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Conflict of interest

The authors have declared that no competing interests exist.

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Affiliations

  1. Department of Colorectal Surgery, Xinhua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China

    Jiwei Sun, Wenjun Ding, Jiajun Zhi & Wei Chen

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  1. Jiwei Sun
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  2. Wenjun Ding
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  3. Jiajun Zhi
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  4. Wei Chen
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Corresponding author

Correspondence to Wei Chen.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Sun, J., Ding, W., Zhi, J. et al. RETRACTED ARTICLE: MiR-200 suppresses metastases of colorectal cancer through ZEB1. Tumor Biol. 37, 15501–15507 (2016). https://doi.org/10.1007/s13277-015-3822-3

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  • DOI: https://doi.org/10.1007/s13277-015-3822-3

Keywords

  • Colorectal cancer
  • ZEB1
  • miR-200