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TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India

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Tumor Biology

Abstract

Breast cancer (BC) is the second most common cancer in women. In the North Eastern Region (NER) of India, BC is emerging as an important concern as evidenced by the data available from population and hospital-based cancer registries. Studies on genetic susceptibility to BC are important to understand the increase in the incidence of BC in NER. The present case control study was conducted to investigate the association between tumour suppressor gene TP53 codon 72 polymorphism and innate immune pathway gene TLR2∆22 (-196-174) polymorphism with BC in females of NER of India for the identification of novel biomarker of BC. Four hundred sixty-two histopathologically confirmed BC cases from four states of NER of India, and 770 healthy controls were included by organizing community surveys from the neighbourhood of cases. In our study, no significant association between TP53 codon 72 polymorphisms and the risk of BC was found. However, our study has shown that TP53 codon 72 polymorphism is an important effect modifier. In the present study it was found that females carrying 22 base-pair deletion in the promoter region of their TLR2 gene had two times (AOR= 2.18, 95 % CI 1.13-4.21, p=0.019 in dominant model; AOR= 2.17, 95 % CI 1.09-4.34, p=0.027 in co-dominant model) increased risk of BC whwn they also carry proline allele at codon 72 of their TP53 gene.

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Acknowledgments

This work was supported by the Indian Council of Medical Research (ICMR), India. We would like to thank all study participants for their cooperation. We are grateful to the editorial board and esteemed referees of the journal ‘Tumor Biology’ for their critical comments to review the manuscript.

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None.

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Authors and Affiliations

  1. Regional Medical Research Centre, N.E. Region (Indian Council of Medical Research), Post Box #105, Dibrugarh, 786 001, Assam, India

    K. Rekha Devi, Kaustab Mukherjee, Rup Kumar Phukan, Jagdish Mahanta, S.K. Rajguru, Debdutta Mukherjee & Kanwar Narain

  2. Civil Hospital, Aizawl Upper Bazar, Aizawl, Mizoram, India

    Saia Chenkual & Jason C. Zonunmawia

  3. Regional Cancer Centre, Agartala, Tripura, India

    Gautam Majumdar

  4. Assam Medical College and Hospital, Dibrugarh, Assam, India

    Jishan Ahmed

  5. Indian Council of Medical Research, New Delhi, India

    Tanvir Kaur

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  1. K. Rekha Devi
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  2. Saia Chenkual
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  3. Gautam Majumdar
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  7. Kaustab Mukherjee
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Correspondence to Kanwar Narain.

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Devi, K.R., Chenkual, S., Majumdar, G. et al. TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India. Tumor Biol. 36, 9995–10002 (2015). https://doi.org/10.1007/s13277-015-3795-2

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