Tumor Biology

, Volume 37, Issue 1, pp 619–625 | Cite as

Serum lactate dehydrogenase levels at presentation in stage IV non-small cell lung cancer: predictive value of metastases and relation to survival outcomes

  • Dong Soo Lee
  • Kyung Ran Park
  • Seung Joon Kim
  • Mi Joo Chung
  • Yun Hee Lee
  • Ji Hyun Chang
  • Jin Hyoung Kang
  • Sook Hee Hong
  • Myung Sin Kim
  • Yeon Sil KimEmail author
Original Article


This study aimed to evaluate the clinical correlations between serum lactate dehydrogenase (LDH) levels and tumor characteristics and to investigate the prognostic impact of serum LDH levels in advanced non-small cell lung cancer (NSCLC). A total of 394 patients were included in the present study between June 2007 and January 2013. All eligible patients had serum LDH levels available before treatment, and whole-body metastatic extent was measured using whole-body metastatic scores, as determined by 18(F)-fludeoxyglucose positron emission tomography scans from 1 to 7 as the sum of each metastatic region. The diagnostic cutoff value for an abnormal serum LDH level was 450 IU/L. The median serum LDH level was 477 IU/L (range, 113–2850), and 224 (56.9 %) patients had abnormal serum LDH levels. The serum LDH levels showed no significant associations with age, gender, histology, tumor differentiation, and smoking history. However, the proportion of patients with abnormal serum LDH levels was statistically significantly higher in the high total metastatic score group (scores 3–7) than in the low total metastatic score group (scores 1–2) (65.3 vs 50.4 %, p = 0.001). In a multivariate survival analysis, age (p = 0.001), gender (p = 0.001), histology (p = 0.003), tumor differentiation (p = 0.001), Eastern Cooperative Oncology Group (ECOG) performance status (p = 0.001), LDH levels (p = 0.046), and treatment factors (p = 0.001) proved to be independent prognostic factors for survival outcomes. The results of this study suggest that the serum LDH levels at presentation may be significantly correlated with whole-body tumor extent and might independently but modestly prognosticate OS in stage IV NSCLC.


Lactate dehydrogenase Metastases Non-small cell lung cancer Prognosis 


Conflict of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Dong Soo Lee
    • 1
  • Kyung Ran Park
    • 2
  • Seung Joon Kim
    • 3
  • Mi Joo Chung
    • 1
  • Yun Hee Lee
    • 1
  • Ji Hyun Chang
    • 1
  • Jin Hyoung Kang
    • 4
  • Sook Hee Hong
    • 4
  • Myung Sin Kim
    • 5
  • Yeon Sil Kim
    • 1
    Email author
  1. 1.Department of Radiation Oncology, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  2. 2.Department of Radiation Oncology, School of MedicineEwha Womans UniversitySeoulSouth Korea
  3. 3.Division of Pulmonology, Department of Internal Medicine, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  4. 4.Department of Medical Oncology, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  5. 5.Department of Laboratory Medicine, College of MedicineThe Catholic University of KoreaSeoulSouth Korea

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