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RETRACTED ARTICLE: miR-203 suppression in gastric carcinoma promotes Slug-mediated cancer metastasis

  • Original Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

MicroRNAs (miRNAs) play critical roles in tumorigenesis and cancer metastasis. Recently, miR-203 was reported as a tumor suppressor microRNA silenced in different malignancies including hepatocellular carcinoma, prostate cancer, oral cancer, breast cancer, and hematopoietic malignancy, whereas its role in the carcinogenesis of gastric carcinoma (GC) has not been evaluated. Here, we analyzed the levels of miR-203 and Slug in the GC specimen and studied their correlation. We analyzed the binding of miR-203 to the 3′-UTR of Slug messenger RNA (mRNA) and its effects on Slug translation by bioinformatics analysis and by luciferase-reporter assay, respectively. We modified miR-203 levels in GC cells and studied their effects on the cell invasiveness in transwell cell migration assay. We found that in GC, miR-203 levels were significantly decreased and Slug levels were significantly increased. miR-203 and Slug inversely correlated in patients’ specimen. Bioinformatic analysis predicted that miR-203 may target the 3′-UTR of Slug mRNA to inhibit its translation, which was confirmed by luciferase-reporter assay. Overexpression of miR-203 inhibited Slug and cell invasiveness, while depletion of miR-203 increased Slug and cell invasiveness. These data suggest that miR-203 suppression in GC promotes Slug-mediated cancer metastasis.

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Acknowledgments

The study is supported by National Science Foundation of China (No.: 81472293).

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    Authors and Affiliations

    1. Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China

      Yan Shi, Yong-jia Tan, Dong-zhu Zeng, Feng Qian & Pei-wu Yu

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    1. Yan Shi
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    2. Yong-jia Tan
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    3. Dong-zhu Zeng
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    4. Feng Qian
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    5. Pei-wu Yu
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    Correspondence to Yan Shi or Pei-wu Yu.

    Additional information

    Yan Shi and Yong-jia Tan contributed equally to this work.

    The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

    An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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    Cite this article

    Shi, Y., Tan, Yj., Zeng, Dz. et al. RETRACTED ARTICLE: miR-203 suppression in gastric carcinoma promotes Slug-mediated cancer metastasis. Tumor Biol. 37, 15483–15488 (2016). https://doi.org/10.1007/s13277-015-3765-8

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    • DOI: https://doi.org/10.1007/s13277-015-3765-8

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