Tumor Biology

, Volume 36, Issue 8, pp 5759–5762 | Cite as

Metabolic reprogramming as a continuous changing behavior of tumor cells

  • Silvia Peppicelli
  • Francesca Bianchini
  • Lido Calorini


Malignant cells resist microenvironment stress and migrate into surrounding tissues in order to divide with the need to adapt their metabolic program. These changes, often strengthened by the tremendous liaison between hypoxia, low glucose, and acidosis, are not yet completely understood. The aim of this perspective is to re-organize a possible comprehensive scenario useful to identify the metabolism occurring in various tumor cell subpopulations endowed with different capabilities.


Cancer metabolism Acidic microenvironment Hypoxia 



Work is supported by grants from Istituto Toscano Tumori and Ente Cassa di Risparmio di Firenze.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Silvia Peppicelli
    • 1
  • Francesca Bianchini
    • 1
  • Lido Calorini
    • 1
  1. 1.Department of Experimental and Clinical Biomedical Sciences, Section of Experimental Pathology and OncologyFlorence UniversityFlorenceItaly

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