Tumor Biology

, Volume 37, Issue 1, pp 299–303 | Cite as

Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer

Research Article


A long ncRNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) in the 8q24 has been reported to be upregulated in prostate cancer with a function of activating androgen receptor (AR). AR plays a key role in the gender disparity, cell migration, and invasion of gastric cancer (GC). We hypothesized that single nucleotide polymorphisms (SNPs) in the lncRNA PRNCR1 may be related to the risk of GC. We conducted a case-control study to investigate the association between SNPs in the lncRNA PRNCR1 and the risk of GC. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay was used to determine the genotypes of 613 subjects including 219 cases with GC and 394 controls. We found that patients with the rs13252298AG genotype displayed a 1.50-fold increased risk of GC (AG vs. AA, 95 % confidence interval (CI) = 1.05–2.12, p = 0.02). Interestingly, the rs7007694CT and CC and the rs1456315GG genotypes displayed a decreased risk of GC (rs7007694CT vs. TT, odds ratio (OR) = 0.68, 95 % CI = 0.48–0.97, p = 0.03; rs7007694CC vs. TT, OR = 0.36, 95 % CI = 0.13–0.97, p = 0.04; rs1456315GG vs. AA, OR = 0.30, 95 % CI = 0.13–0.70, p = 0.004, respectively). Our results suggest that SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC.


Gastric cancer lncRNAs Polymorphism 



This work was supported by the National Natural Science Foundation of China (no. 81302149 and 81202387), Distinguished Young Scientist of Sichuan University (no. 2013SCU04A38), the Science and Technology Pillar Program of Sichuan Province (2014KJT059-2014SZ0001), and the PhD Programs Foundation of the Ministry of Education of China (no. 20130181120011).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Forensic MedicineMedical College of Soochow UniversitySuzhouPeople’s Republic of China
  2. 2.Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University HospitalSichuan UniversityChengduPeople’s Republic of China
  3. 3.Department of Orthopedics, National Clinical Key Specialty, Yanan HospitalKunming Medical UniversityKunmingPeople’s Republic of China
  4. 4.Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan UniversityChengduPeople’s Republic of China
  5. 5.Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University HospitalSichuan UniversityChengduPeople’s Republic of China

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