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Tumor Biology

, Volume 36, Issue 12, pp 9919–9927 | Cite as

High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma

  • Yan Cui
  • Ming Niu
  • Xianyu Zhang
  • Zhenbin Zhong
  • Ji Wang
  • Da Pang
Research Article

Abstract

Valosin-containing protein (VCP) is one of the AAA-ATPase superfamily members. The correlation between elevated expression of VCP and progression, prognosis, and the metastatic potential has been identified in various tumor types. However, the clinical impact of VCP in breast carcinoma has not been investigated. In the current study, the expression of VCP in 421 breast tumors and adjacent normal breast tissues was examined to investigate the correlation between VCP expression and clinicopathological features in patients with breast carcinoma. We found that the expression of VCP correlated with the TNM stage, Ki67 labeling, and lymph node metastasis (LNM). The expression of VCP was increased significantly in the cytoplasm of cancer cells compared to normal mammary epithelial cells, which was associated with decreased overall survival rates of patients with breast carcinoma (P < 0.001). In conclusion, this study demonstrates significant correlation between the cytoplasmic expression of VCP and adverse prognosis in breast carcinoma, suggesting that VCP may serve as a prognostic biomarker in breast carcinoma.

Keywords

VCP Breast cancer Prognosis Immunohistochemistry 

Notes

Acknowledgments

This study was supported by funding from the Heilongjiang Province Applied Technology Research and Development Project (No. GA13C201), the National Key Technology Support Program (No. 2013BAI09B00), and the National Natural Science Foundation of China (No. 81172498/H1622).

Conflict of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yan Cui
    • 1
  • Ming Niu
    • 1
  • Xianyu Zhang
    • 1
  • Zhenbin Zhong
    • 1
  • Ji Wang
    • 1
  • Da Pang
    • 1
  1. 1.Department of Breast SurgeryHarbin Medical University Cancer HospitalHarbinChina

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