Tumor Biology

, Volume 36, Issue 12, pp 9807–9812 | Cite as

Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer

  • Shou-ping Xu
  • Jin-feng Zhang
  • Shi-yao Sui
  • Nan-xia Bai
  • Song Gao
  • Guang-wen Zhang
  • Qing-yu Shi
  • Zi-long You
  • Chao Zhan
  • Da Pang
Research Article

Abstract

Eosinophil granule ontogeny transcript (EGOT) is a long noncoding RNA involved in the regulation of eosinophil granule protein transcript expression. However, little is known about the role of EGOT in malignant disease. This study aimed to assess the potential role of EGOT in the pathogenesis of breast cancer. Quantitative real-time polymerase chain reaction was performed to detect the expression levels of EGOT in 250 breast cancerous tissues and 50 adjacent noncancerous tissues. The correlation of EGOT expression with clinicopathological features and prognosis was also analyzed. EGOT expression was lower in breast cancer compared with the adjacent noncancerous tissues (P < 0.001), and low levels of EGOT expression were significantly correlated with larger tumor size (P = 0.022), more lymph node metastasis (P = 0.020), and higher Ki-67 expression (P = 0.017). Moreover, patients with low levels of EGOT expression showed significantly worse prognosis for overall survival (P = 0.040), and this result was further validated in a larger cohort from a public database. Multivariate analysis suggested that low levels of EGOT were a poor independent prognostic predictor for breast cancer patients (HR = 1.857, 95 % CI = 1.032–3.340, P = 0.039). In conclusion, EGOT may play an important role in breast cancer progression and prognosis and may serve as a new potential prognostic target in breast cancer patients.

Keywords

Breast cancer Long noncoding RNA EGOT Prognosis 

Notes

Acknowledgments

The study was supported by research grants from the Harbin Medical University Graduate Student Innovation Fund Project (YJSCX2014-03HYD) and Haiyan Fund Project of Harbin Medical University Cancer Hospital (JJMS2014-05).

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Shou-ping Xu
    • 1
  • Jin-feng Zhang
    • 1
  • Shi-yao Sui
    • 1
  • Nan-xia Bai
    • 1
  • Song Gao
    • 1
  • Guang-wen Zhang
    • 1
  • Qing-yu Shi
    • 1
  • Zi-long You
    • 1
  • Chao Zhan
    • 1
  • Da Pang
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Breast SurgeryHarbin Medical University Cancer HospitalHarbinChina
  2. 2.Heilongjiang Academy of Medical SciencesHarbinChina
  3. 3.Sino-Russian Medical Research CenterHeilongjiang Academy of Medical SciencesHarbinChina
  4. 4.Northern (China) Translational Medicine Research and Cooperation CenterHeilongjiang Academy of Medical SciencesHarbinChina

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