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RETRACTED ARTICLE: SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

SUMOylation is a post-translational modification exerted various effects on the target proteins. SUMOylation is a highly dynamic and reversible process, which has been shown to play an important role in tumorigenesis. However, the roles of sentrin/SUMO-specific proteases (SENPs), which mediate the reverse process of SUMOylation, in tumorigenesis remains largely unexplored. Here, we uncover a critical role of SENP6 in promoting gastric cancer cells growth via regulating the deSUMOylation of a transcription factor forkhead box protein M1 (FoxM1). We demonstrated that the mRNA and protein levels were elevated in gastric cancer tissues. Overexpression of SENP6 promoted, while RNA interference depletion of endogenous SENP6 inhibited gastric cancer cells growth and the ability of colony formation. By using biochemical assays, we identified FoxM1 as a novel substrate of SENP6 in gastric cancer cells. Thus, our data suggest that SENP6, which is highly expressed in gastric cancer cells, regulates the transcriptional activity and stability of FoxM1 through deSUMOylation.

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Acknowledgments

We thank Dr. Liu at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences for providing FoxM1-TATA-luciferase reporter plasmid. This work was supported by grants from the National Natural Science Foundation of China (No. 81101852) and the National Health and Family Planning Commission of China (No. W2012FZ093).

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Authors and Affiliations

  1. Department of Gastroenterology, The 309th Hospital of Chinese People’s Liberation Army, Beijing, China

    Jiu-Gang Song, Nan Li & Kai Wu

  2. State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, China

    Hua-Hong Xie

  3. Department of General Surgery, Huadong Hospital, Fudan University, Shanghai, China

    Ji-gang Qiu, Da-Ming Shen & Chun-Jin Huang

Authors
  1. Jiu-Gang Song
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  2. Hua-Hong Xie
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  3. Nan Li
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  4. Kai Wu
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  5. Ji-gang Qiu
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  6. Da-Ming Shen
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  7. Chun-Jin Huang
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Corresponding author

Correspondence to Ji-gang Qiu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Song, JG., Xie, HH., Li, N. et al. RETRACTED ARTICLE: SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1. Tumor Biol. 36, 9865–9871 (2015). https://doi.org/10.1007/s13277-015-3737-z

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  • DOI: https://doi.org/10.1007/s13277-015-3737-z

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