Transforming growth factor β type II receptor as a marker in diffuse large B cell lymphoma
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The objective of this study was to investigate the expression and significance of the transforming growth factor β type II receptor (TGFβRII) in diffuse large B cell lymphoma. All patients were enrolled at the First Affiliated Hospital of Liaoning Medical University between 2001 and 2007. The median follow-up period was 53.3 months. Of the 338 patients studied, 131 (38.76 %) had TGFβRII positive expression on immunohistochemistry. The 5 year survival rate was significantly higher in patients with TGFβRII expression than in those without TGFβRII expression (40.3 vs. 31.6 %, P = 0.041). Multivariate analysis identified TGFβRII expression as an independent predictive parameter for survival, in addition to lactate dehydrogenase, clinical stage, and histologic subtype. TGFβRII expression may be considered a new prognostic factor of diffuse large B cell lymphoma.
KeywordsDiffuse large B cell lymphoma Survival TGFβRII
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Conflicts of interest
The study protocol was approved by the Ethics Committee of Liaoning Medical University, and written informed consent was obtained from all participants involved in the study.
Shudan Mao and Wenqi Yang conducted the experiments and drafted the manuscript. Zhe Li and Limei Ai participated in the design of the study and performed the statistical analysis. Jieping Jin conceived the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.
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