Tumor Biology

, Volume 36, Issue 12, pp 9373–9383 | Cite as

Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma

  • Haijian Zhang
  • Min Yao
  • Wei Wu
  • Liwei Qiu
  • Wenli Sai
  • Junling Yang
  • Wenjie Zheng
  • Jianfei Huang
  • Dengfu Yao
Research Article


Hepatic annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical symptoms and plays a key role in development, metastasis, and drug resistance of lethal hepatocellular carcinoma (HCC). However, the prognostic significance of ANXA2 for HCC has not been elucidated up to now. In this study, ANXA2 was frequently found to be up-regulated in HCC tissues compared with benign liver disease (BLD) tissues, which was consistent with the results in serum samples and tissue specimens of patients with HCC. Furthermore, ANXA2 expression was significantly correlated with differentiated degree, intrahepatic metastasis, portal vein thrombus, and tumor node metastasis (TNM) staging. More importantly, increased ANXA2 level was first confirmed to be closely associated with shortened overall survival of HCC (χ 2 = 12.872, P = 0.005) and identified as an independent prognostic factor (hazard ratio 1.338, 95 % confidence interval (CI) 1.013 ~ 1.766, P = 0.040), suggesting that ANXA2 up-regulation might represent an acquired metastasis phenotype of HCC, help to screen out high-risk population for HCC, or more effectively treat a subset of postsurgical HCC patients positive for ANXA2.


Annexin A2 Up-regulation Prognosis Hepatocellular carcinoma 



Hepatocellular carcinoma


Annexin A2


Benign liver diseases


Tissue microarray


Formalin-fixed paraffin-embedded


Enzyme-linked immunosorbent assay


Phosphate-buffered saline


Quantitative real-time polymerase chain reaction




Standard deviation


Tissue plasminogen activator





This study was supported by grants from the National Natural Science Foundation of China (81401988), the Academic Program Development of Jiangsu Higher Education Institution (PAPD), and the International S&T Cooperation Program of China (2013DFA32150).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Haijian Zhang
    • 1
  • Min Yao
    • 2
  • Wei Wu
    • 1
  • Liwei Qiu
    • 1
  • Wenli Sai
    • 1
  • Junling Yang
    • 1
  • Wenjie Zheng
    • 1
  • Jianfei Huang
    • 3
  • Dengfu Yao
    • 1
  1. 1.Research Center of Clinical MedicineAffiliated Hospital of Nantong UniversityJiangsuChina
  2. 2.Department of ImmunologyMedical School of Nantong UniversityNantongChina
  3. 3.Department of PathologyAffiliated Hospital of Nantong UniversityNantongChina

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