Tumor Biology

, Volume 36, Issue 11, pp 8805–8809 | Cite as

Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma

  • Hua Zhang
  • Lei Zhao
  • Ying-Xue Wang
  • Mian Xi
  • Shi-Liang Liu
  • Li-Ling Luo
Research Article


Long non-coding RNAs (lncRNAs) have been demonstrated to be a critical role in cancer progression and prognosis. However, little is known about the pathological role of lncRNA HOXA transcript at the distal tip (HOTTIP) in tongue squamous cell carcinoma (TSCC) patients. The aim of this study is to measure the expression of lncRNA HOTTIP in TSCC patients and to explore the clinical significance of the lncRNA HOTTIP. The expression of lncRNA HOTTIP was measured in 86 TSCC tissues and 14 adjacent non-malignant tissues using qRT-PCR. In our study, results indicated that lncRNA HOTTIP was highly expressed in TSCC compared with adjacent non-malignant tissues (P < 0.001) and positively correlated with T stage (T1–2 vs. T3–4, P = 0.023), clinical stage (I–II stages vs. III–IV stages, P = 0.018), and distant metastasis (absent vs. present, P = 0.031) in TSCC patients. Furthermore, we also found that lncRNA HOTTIP overexpression was an unfavorable prognostic factor in TSCC patients (P < 0.001), regardless of T stage, distant metastasis, and clinical stage. Finally, overexpression of lncRNA HOTTIP was supposed to be an independent poor prognostic factor for TSCC patients through multivariate analysis (P = 0.023). In conclusion, increased lncRNA HOTTIP expression may be serve as an unfavorable prognosis predictor for TSCC patients. Nevertheless, further investigation with a larger sample size is needed to support our results.


lncRNA HOTTIP Tongue squamous cell carcinoma Prognosis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Hua Zhang
    • 1
  • Lei Zhao
    • 2
    • 3
    • 4
    • 6
  • Ying-Xue Wang
    • 5
  • Mian Xi
    • 2
    • 3
    • 4
  • Shi-Liang Liu
    • 2
    • 3
    • 4
  • Li-Ling Luo
    • 2
    • 3
    • 4
  1. 1.Department of Stomatologythe First Affiliated Hospital of Jinan UniversityGuangzhouChina
  2. 2.Department of Radiation OncologySun Yat-Sen University Cancer CenterGuangzhouChina
  3. 3.State Key Laboratory of Oncology in South ChinaSun Yat-Sen University Cancer CenterGuangzhouChina
  4. 4.Collaborative Innovation Center for Cancer MedicineGuangzhouChina
  5. 5.Department of Hepatobiliary Surgery, Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina
  6. 6.Department of Radiotherapy, Cancer CenterSun Yat-Sen UniversityGuangzhouChina

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