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Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy

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Tumor Biology

Abstract

Although pretreatment neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients with bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely investigated. We analyzed relationships between preoperative NLR, LMR, PLR, and overall survival (OS) in 124 BCa patients undergoing RC. OS curves were drawn using the Kaplan–Meier method and evaluated using the log-rank test. Relationships between OS and potential confounding variables were determined using Cox’s proportional hazard regression model. Decreased LMR was associated with shorter OS (P = 0.012); OS in the low PLR group was significantly longer than that in the high PLR group (P = 0.029), and NLR was not significantly associated with oncological outcomes. However, after adjusting for confounding variables, patients in the high-LMR group indicated >30 % decreased mortality than the low-LMR group (hazard ratio 0.674; 95 % confidence interval 0.412–0.890; P = 0.003), and PLR was not an independent predictor of OS. Our results show that preoperative LMR is a better prognostic factor in BCa patients undergoing RC, compared with NLR and PLR.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (grant number: 81302216).

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    Authors and Affiliations

    1. Department of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, China

      Gui-Ming Zhang, Yao Zhu, Fang-Ning Wan, Yi-Ping Zhu & Ding-Wei Ye

    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

      Gui-Ming Zhang & Ding-Wei Ye

    3. Department of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Rd., Qingdao, Shandong, 266003, China

      Lei Luo & Li-Jiang Sun

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    1. Gui-Ming Zhang
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    2. Yao Zhu
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    Correspondence to Li-Jiang Sun or Ding-Wei Ye.

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    Gui-Ming Zhang and Yao Zhu contributed equally to this work.

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    Zhang, GM., Zhu, Y., Luo, L. et al. Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy. Tumor Biol. 36, 8537–8543 (2015). https://doi.org/10.1007/s13277-015-3613-x

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