Tumor Biology

, Volume 36, Issue 11, pp 8333–8340 | Cite as

SEMA6A is a prognostic biomarker in glioblastoma

  • Jiaxin Zhao
  • Haitao Tang
  • Hong Zhao
  • Wanli Che
  • Lei Zhang
  • Peng Liang
Research Article


Glioblastoma multiforme (GBM) is one of the most aggressive tumors in the central nervous system. SEMA6A, the first identified class 6 semaphorin, is contributed to regulate vascular development and adult angiogenesis. However, the function of SEMA6A in GBM is still undefined. In the present study, we investigated the expression of SEMA6A protein in 200 GBM tissues using immunohistochemistry (IHC). SEMA6A expression was associated with time to progression (P = 0.001) and mean tumor diameter (P = 0.038). Kaplan–Meier analysis revealed that patients expressing high SEMA6A protein levels had a significantly longer overall survival (OS, P = 0.013) and progression-free survival (PFS, P = 0.005) compared to those with low SEMA6A expression level. Cox multivariate regression analysis confirmed that low SEMA6A expression was an independent unfavorable prognostic factors for PFS (HR, 1.896; 95 % CI, 1.147–2.768; P = 0.009) and OS (HR, 1.712; 95 % CI, 1.011–2.657; P = 0.012). Furthermore, in vitro experiments showed that SEMA6A could inhibit proliferation, migration, and invasion in different glioma cell lines. In conclusion, our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of GBM.


SEMA6A Glioblastoma multiforme (GBM) Prognosis Proliferation Invasion 



This work was supported by the Health and Family Planning Commission of Heilongjiang Province [grant number 2014-403].

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Jiaxin Zhao
    • 1
  • Haitao Tang
    • 2
  • Hong Zhao
    • 3
  • Wanli Che
    • 4
  • Lei Zhang
    • 4
  • Peng Liang
    • 4
  1. 1.Department of NeurosurgeryThe Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of NeurosurgeryThe General Hospital of Daqing Oil FieldDaqingChina
  3. 3.Department of Medical OncologyThe Third Affiliated Hospital of Harbin Medical UniversityHarbinChina
  4. 4.Department of NeurosurgeryThe Third Affiliated Hospital of Harbin Medical UniversityHarbinChina

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