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SEMA6A is a prognostic biomarker in glioblastoma

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Tumor Biology

Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive tumors in the central nervous system. SEMA6A, the first identified class 6 semaphorin, is contributed to regulate vascular development and adult angiogenesis. However, the function of SEMA6A in GBM is still undefined. In the present study, we investigated the expression of SEMA6A protein in 200 GBM tissues using immunohistochemistry (IHC). SEMA6A expression was associated with time to progression (P = 0.001) and mean tumor diameter (P = 0.038). Kaplan–Meier analysis revealed that patients expressing high SEMA6A protein levels had a significantly longer overall survival (OS, P = 0.013) and progression-free survival (PFS, P = 0.005) compared to those with low SEMA6A expression level. Cox multivariate regression analysis confirmed that low SEMA6A expression was an independent unfavorable prognostic factors for PFS (HR, 1.896; 95 % CI, 1.147–2.768; P = 0.009) and OS (HR, 1.712; 95 % CI, 1.011–2.657; P = 0.012). Furthermore, in vitro experiments showed that SEMA6A could inhibit proliferation, migration, and invasion in different glioma cell lines. In conclusion, our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of GBM.

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Acknowledgments

This work was supported by the Health and Family Planning Commission of Heilongjiang Province [grant number 2014-403].

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Neurosurgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Yiyuan Road No. 37 of Nangang District, Harbin, 150001, Heilongjiang, China

    Jiaxin Zhao

  2. Department of Neurosurgery, The General Hospital of Daqing Oil Field, Zhongkang Road 9 of Saertu District, Daqing, 163001, Heilongjiang, China

    Haitao Tang

  3. Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Haping Road No. 150 of Nangang District, Harbin, 150081, Heilongjiang, China

    Hong Zhao

  4. Department of Neurosurgery, The Third Affiliated Hospital of Harbin Medical University, Haping Road 150 of Nangang District, Harbin, 150081, Heilongjiang, China

    Wanli Che, Lei Zhang & Peng Liang

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  1. Jiaxin Zhao
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  2. Haitao Tang
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  3. Hong Zhao
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  4. Wanli Che
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  6. Peng Liang
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Corresponding author

Correspondence to Peng Liang.

Additional information

Jiaxin Zhao and Haitao Tang contributed equally to the work and should be considered co-first authors.

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Zhao, J., Tang, H., Zhao, H. et al. SEMA6A is a prognostic biomarker in glioblastoma. Tumor Biol. 36, 8333–8340 (2015). https://doi.org/10.1007/s13277-015-3584-y

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  • DOI: https://doi.org/10.1007/s13277-015-3584-y

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