Skip to main content

Advertisement

SpringerLink
Log in

RETRACTED ARTICLE: Clinical significance of CUL4A in human prostate cancer

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Aberrant expression of the Cullin 4A (CUL4A) is found in many tumor types, but the functions and mechanism of CUL4A in prostate cancer (PCa) development and progression remain largely unknown. The aim of this study was to investigate the possible role of CUL4A in prostate tumorigenesis. Immunohistochemistry was used to examine CUL4A expression in human PCa tissues and BPH tissues. Cell proliferation was assessed by MTT, and migration and invasion were analyzed by Transwell and Matrigel assays after CUL4A knockdown in PCa in vitro. The results showed that CUL4A protein was overexpressed in 86.21 % of PCa tissues. CUL4A knockdown with siRNA in PCa cells decreased cell proliferation, migration, and invasion. Mechanistically, CUL4A could modulate the expression of P53 in PCa cells. Our results indicate that CUL4A overexpression play an oncogenic role in the pathogenesis of PCa, and CUL4A may be a potential therapeutic target for PCa.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.

    Article  PubMed  Google Scholar 

  2. Zhang L, Yang BX, Zhang HT, Wang JG, Wang HL, et al. Prostate cancer: an emerging threat to the health of aging men in Asia. Asian J Androl. 2011;13:574–8.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ma Y, Yang HZ, Dong BJ, Zou HB, Zhou Y, Kong XM, et al. Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia. Oncotarget. 2014;5(19):9169–82.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Birner P, Schoppmann A, Schindl M, Dinhof C, Jesch B, Berghoff AS, et al. Human homologue for Caenorhabditis elegans CUL-4 protein overexpression is associated with malignant potential of epithelial ovarian tumours and poor outcome in carcinoma. J Clin Pathol. 2012;65(6):507–11.

    Article  PubMed  Google Scholar 

  5. Lee J, Zhou P. Pathogenic role of the CRL4 ubiquitin ligase in human disease. Front Oncol. 2012;2:21.

    PubMed  PubMed Central  Google Scholar 

  6. Sugasawa K. The CUL4 enigma: culling DNA repair factors. Mol Cell. 2009;34:403–4.

    Article  CAS  PubMed  Google Scholar 

  7. Nag A, Bagchi S, Raychaudhuri P. Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res. 2004;64:8152–5.

    Article  CAS  PubMed  Google Scholar 

  8. Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, et al. CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell. 2009;34:451–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, et al. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol. 2006;26:2531–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Gupta A, Yang LX, Chen L. Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene. Int J Radiat Oncol Biol Phys. 2002;52:822–30.

    Article  CAS  PubMed  Google Scholar 

  11. Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, et al. Cul4A is an oncogene in malignant pleural mesothelioma. J Cell Mol Med. 2011;15:350–8.

    Article  CAS  PubMed  Google Scholar 

  12. Schindl M, Gnant M, Schoppmann SF, Horvat R, Birner P. Overexpression of the human homologue for Caenorhabditis elegans cul-4 gene is associated with poor outcome in nodenegative breast cancer. Anticancer Res. 2007;27:949–52.

    CAS  PubMed  Google Scholar 

  13. Li B, Jia N, Kapur R, Chun KT. Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood. 2006;107:4291–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J Biol Chem. 2008;283:29045–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. El-Mahdy MA, Zhu Q, Wang QE, Wani G, Praetorius-Ibba M, Wani AA. Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC. J Biol Chem. 2006;281:13404–11.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Urology, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China

    Gang Liu, Zengjun Zhu, Fang Lang, Bao Li & Dianjun Gao

Authors
  1. Gang Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zengjun Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fang Lang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bao Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dianjun Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zengjun Zhu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, G., Zhu, Z., Lang, F. et al. RETRACTED ARTICLE: Clinical significance of CUL4A in human prostate cancer. Tumor Biol. 36, 8553–8558 (2015). https://doi.org/10.1007/s13277-015-3580-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-015-3580-2

Keyword

Search

Navigation