Tumor Biology

, Volume 36, Issue 11, pp 8609–8615 | Cite as

RETRACTED ARTICLE: A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma

  • Jian Zhao
  • Zhongyu Kong
  • Feng Xu
  • Wei Shen
Research Article


Although matrix metalloproteinase 14 (MMP-14) has been shown to play a substantial role in the carcinogenesis of some types of cancer, its involvement in the pathogenesis of nasopharyngeal carcinoma (NPC) has not been reported. Here, we analyzed MMP-14 levels in the NPC specimens from patients and compared with the paired normal nasopharynx (NNP) tissues. We found that NPC had significantly higher messenger RNA (mRNA) and protein levels of MMP-14. Moreover, higher levels of MMP-14 correlated with more advanced status of clinical stage and lymphatic metastasis. In vitro, MMP-14 levels determined the potential of invasiveness of NPC cells, possibly through induction of EMT-associated genes. Our data thus highlight MMP-14 as a novel therapeutic target for NPC.


Matrix metalloproteinase 14 (MMP-14) Nasopharyngeal carcinoma (NPC) Metastasis Epithelial-mesenchymal transition (EMT) 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Putuo HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

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