Tumor Biology

, Volume 36, Issue 11, pp 8727–8733 | Cite as

Gabarapl1 mediates androgen-regulated autophagy in prostate cancer

  • Chong-Wei Xie
  • You Zhou
  • Sheng-Lin Liu
  • Zheng-Yu Fang
  • Bing Su
  • Wei Zhang
Research Article


Autophagy plays an important role in prostate cancer development. It promotes tumor cell survival and was found to be associated with androgen pathway. In the present study, we found that GABA(A) receptor-associated protein like 1 (Gabarapl1), a ubiquitin-like modifier, participates in the regulation of autophagy. Gabarapl1 is transcriptionally regulated by androgen receptor (AR) and has a repressive role in autophagy. Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of autophagy flux. Elevated Gabarapl1 also represses the proliferation of prostate cancer cells. In summary, our study provides evidence to show that Gabarapl1 is a mediator involved in androgen-regulated autophagy process.


Gabarapl1 Autophagy Androgen Prostate cancer 



The study was supported by National Science Foundation (81272380) and Shenzhen Emerging Industry Foundation (JCYJ20130329110752141).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Biomedical Research InstituteShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenChina
  2. 2.Xinxiang Key Lab of Translational Cancer Research, The Third Affiliated HospitalXinxiang Medical UniversityXinxiangChina
  3. 3.Department of Epidemiology and Environmental Health, School of Public Health and Health ProfessionsThe State University of New YorkBuffaloUSA

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