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Tumor Biology

, Volume 36, Issue 11, pp 8679–8683 | Cite as

Clinicopathological significance and biological role of TCF21 mRNA in breast cancer

  • Jie Wang
  • Xueren Gao
  • Mingxi Wang
  • Jianqiong Zhang
Research Article

Abstract

TCF21 is known to function as a tumor suppressor and deregulated in several types of cancers; however, its role in breast cancer remains poorly understood. The aim of this study was to examine the expression of TCF21 messenger RNA (mRNA) in breast cancer and evaluate its clinical significance and biological role in tumor progression. TCF21 mRNA expression was analyzed in breast cancer cell lines and tissues by qRT-PCR. Overexpression approach was used to investigate the biological functions of TCF21 mRNA in breast cancer cell line (MDA-MB-231). A notably lower level of TCF21 mRNA expression was found in breast cancer cell lines and tissues. Furthermore, the low expression of TCF21 mRNA was associated with large tumor size and positive lymph node metastasis. Functional analysis showed that overexpression of TCF21 mRNA inhibited cell proliferation and epithelial-mesenchymal transition (EMT) of MDA-MB-231. In conclusion, our data provided the first evidence that TCF21 mRNA is significantly downregulated in breast cancer cell lines and tissues and regulates breast cancer cell proliferation and EMT. Thus, TCF21 may act as a potential therapeutic target for breast cancer intervention.

Keywords

TCF21 mRNA Breast cancer Tumor suppressor Proliferation 

Notes

Acknowledgments

This research was supported by the National Nature Science Foundation of China (81371609) and Postgraduate Research and Innovation Project in University of Jiangsu Province (CXLX13_078).

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Jie Wang
    • 1
  • Xueren Gao
    • 1
  • Mingxi Wang
    • 2
  • Jianqiong Zhang
    • 1
  1. 1.Key Laboratory of Developmental Genes and Human Disease, Ministry of Education; Department of Microbiology and ImmunologyMedical School Southeast UniversityNanjingChina
  2. 2.Department of Medical OncologyThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina

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