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Tumor Biology

, Volume 36, Issue 10, pp 7711–7716 | Cite as

RETRACTED ARTICLE: Transforming growth factor β receptor signaling restrains growth of pancreatic carcinoma cells

Research Article

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant. Efficient control of cancer growth may substantially improve the survival of PDAC patients. However, no efficient treatments are so far available. Here, we inhibited transforming growth factor β (TGFβ) receptor signaling by overexpression of a key inhibitor of this pathway, SMAD7, in the mouse pancreas, using a recently developed intraductal infusion method. Overexpression of SMAD7 significantly increased growth of both implanted PDAC and PDAC by K-ras modification. Our data thus suggest that TGFβ receptor signaling restrains growth of PDAC, and modulation of TGFβ receptor signaling may be an effective treatment for PDAC.

Key words

Pancreatic ductal adenocarcinoma (PDAC) TGFβ Cancer growth Intraductal infusion 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Surgical OncologyChinese PLA General HospitalBeijingChina
  2. 2.Department of Hepatobiliary SurgeryThe Hospital of Shunyi DistrictBeijingChina
  3. 3.Department of Surgical OncologyChinese PLA General HospitalBeijingChina

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