Tumor Biology

, Volume 36, Issue 6, pp 4027–4037 | Cite as

Long non-coding RNA functions in lung cancer

  • Haiwei Sang
  • Haihong Liu
  • Peng Xiong
  • Min Zhu


Numerous long non-coding RNAs (lncRNAs) have been discovered as a result of advances in sequencing methods in genomic research. Recent evidence indicates that lncRNAs may serve as gene regulators via various mechanisms, such as translational control. Dysregulation of lncRNAs contributes to the development and progression of several human diseases, notably lung cancer, which is one of the leading causes of cancer-associated death. Recent studies have identified key roles for molecules such as p53 and polycomb repressive complex 2 (PRC2) in carcinogenesis and the anti-carcinogenic action of lncRNAs. These findings point to the potential of lncRNAs as prospective diagnostic and prognostic biomarkers in lung cancer. In this review, we consider the functions of lncRNAs in translational control and discuss their involvement in lung cancer via p53, PRC2, and other pathways. We also consider the effects of modulating the levels and functions of lncRNAs. Further characterization of these lung cancer-associated lncRNAs will provide a better understanding of their potential roles as therapeutic targets.


Lung cancer Long non-coding RNAs Translational control p53 PRC2 Biomarkers 



This study was supported by grants from the National Natural Science Foundation of China (Grant number 81172786) and Youth Chenguang project of Science and Technology of Wuhan City (Grant number 201050231077).

Conflict of interests



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Thoracic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Emergency Surgery, Affiliated Anhui Provincial HospitalAnhui Medical UniversityHefeiChina

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