Tumor Biology

, Volume 36, Issue 6, pp 4005–4016 | Cite as

Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

  • Gaurav Kumar
  • Hardeep Singh Tuli
  • Sonam Mittal
  • Jitendra Kumar Shandilya
  • Anil Tiwari
  • Sardul Singh Sandhu
Review

Abstract

In recent years, growing interest has been focused on the field of chemoprevention using natural therapies. The reason to turn toward “natural” remedies is associated with diverse beneficial pharmacological properties of natural compounds. Isothiocyanates (ITCs), the major pharmacological active constituents of cruciferous vegetables, are derived from the enzymatic hydrolysis of glucosinolates (GSLs). ITCs govern many intracellular targets including cytochrome P 450 (CYP) enzymes, proteins involved in antioxidant response, tumorigenesis, apoptosis, cell cycle, and metastasis. Investigation of the mechanisms of anti-cancer drugs has given important information regarding the use of natural chemopreventive compounds. This extensive review covers various molecular aspects of the interactions of ITCs with their recognized cellular targets involved in cancer treatment in order to enhance anti-tumor outcome with decreased toxicity to patients.

Keywords

Isothiocyanates Cancer Apoptosis Metastasis Tubulin 

Notes

Acknowledgments

The authors would like to acknowledge Kurukshetra University, Kurukshetra (India) for providing the requisite facilities to perform this study.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Gaurav Kumar
    • 1
  • Hardeep Singh Tuli
    • 2
  • Sonam Mittal
    • 3
  • Jitendra Kumar Shandilya
    • 4
  • Anil Tiwari
    • 4
  • Sardul Singh Sandhu
    • 5
  1. 1.Department of BiochemistryKurukshetra UniversityKurukshetraIndia
  2. 2.Department of MicrobiologyKurukshetra UniversityKurukshetraIndia
  3. 3.School of BiotechnologyJawaharlal Nehru UniversityNew DelhiIndia
  4. 4.Department of ImmunopathologyPGIMERChandigarhIndia
  5. 5.Department of Biological SciencesR. D. UniversityJabalpurIndia

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